Abstract | PURPOSE: METHODS: Descriptive retrospective analyses of icatibant reinjection were performed on Icatibant Outcome Survey data (February 2008 to December 2012). New attacks were defined as the onset of new symptoms after full resolution of the previous attack. Potential associations between the patient and attack characteristics and reinjection were explored by using logistic regression analysis. RESULTS:
Icatibant was administered for 652 attacks in 170 patients with HAE type I or II. Most attacks (89.1%) were treated with a single icatibant injection. For attacks that required two or three injections, the second injection was given a median of 11.0 hours after the first injection, with 90.4% of second injections administered ≥6 hours after the first injection. Time to resolution and attack duration were significantly longer for two or three injections versus one icatibant injection (p < 0.0001 and p < 0.05, respectively). Multivariate logistic regression analysis identified sex, attack severity, and laryngeal attacks as significantly correlated with reinjection (all p ≤ 0.05). These factors did not remain predictors for reinjection when two outlier patients with distinct patterns of icatibant use were excluded. CONCLUSIONS: In this real-world setting, most HAE attacks resolved with one icatibant injection. There was no distinct profile for patients or attacks that required reinjection when outliers with substantially different patterns of use were excluded. Because new attacks were not distinguished from the recurrence of symptoms, reinjection rates may be slightly higher than shown here. Clinical trial identifier: NCT01034969.
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Authors | Hilary J Longhurst, Werner Aberer, Laurence Bouillet, Teresa Caballero, Vincent Fabien, Andrea Zanichelli, Marcus Maurer, IOS Investigators |
Journal | Allergy and asthma proceedings
(Allergy Asthma Proc)
2015 Sep-Oct
Vol. 36
Issue 5
Pg. 399-406
ISSN: 1539-6304 [Electronic] United States |
PMID | 26314822
(Publication Type: Clinical Trial, Phase III, Journal Article, Multicenter Study, Patient Education Handout, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bradykinin B2 Receptor Antagonists
- Receptor, Bradykinin B2
- icatibant
- Bradykinin
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Topics |
- Adolescent
- Adult
- Bradykinin
(administration & dosage, analogs & derivatives, pharmacology)
- Bradykinin B2 Receptor Antagonists
(administration & dosage, pharmacology)
- Drug Administration Schedule
- Female
- Hereditary Angioedema Types I and II
(diagnosis, drug therapy)
- Humans
- Injections
- Male
- Middle Aged
- Receptor, Bradykinin B2
(metabolism)
- Retrospective Studies
- Surveys and Questionnaires
- Treatment Outcome
- Young Adult
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