Recovery of the Corneal Stroma Associated With Rapid Reepithelialization Induced by the Fibronectin-Derived Peptide PHSRN in 2 Cases of Corneal Perforation Due to a Persistent Epithelial Defect.

Abstract

PURPOSE:

To report 2 cases of corneal perforation associated with a persistent epithelial defect (PED), which were treated with eye drops containing the fibronectin-derived peptide PHSRN (Pro-His-Ser-Arg-Asn).

METHODS:

A 67-year-old man and a 58-year-old man presented with corneal perforation associated with a PED caused by lagophthalmos. PHSRN eye drops were administered 4 times a day to both patients.

RESULTS:

Both patients experienced healing of the epithelial defect and closure of corneal perforation within 3 or 4 days after the onset of PHSRN treatment. Anterior segment optical coherence tomography also revealed recovery of corneal stromal thickness at the lesion site.

CONCLUSIONS:

PHSRN eye drops were effective for the treatment of corneal perforation due to the PED, with rapid reepithelialization being followed by full restoration of stromal thickness.

• Authors: Yukiko Morita, Naoyuki Morishige, Naoyuki Yamada, Manami Ohta, Koh-Hei Sonoda, Teruo Nishida
• Journal: Cornea (Cornea) Vol. 34 Issue 11 Pg. 1504-7 (Nov 2015) ISSN: 1536-4798 [Electronic] United States
• PMID: 26312620 (Publication Type: Case Reports, Journal Article)

Chemical References

• Fibronectins
• Ophthalmic Solutions
• Peptide Fragments
• prolyl-histidyl-seryl-arginyl-asparagine

Topics

• Administration, Topical
• Aged
• Corneal Diseases (complications)
• Corneal Perforation (drug therapy, etiology, physiopathology)
• Epithelium, Corneal (pathology)
• Fibronectins (administration & dosage)
• Humans
• Male
• Middle Aged
• Ophthalmic Solutions
• Peptide Fragments (administration & dosage)
• Re-Epithelialization (drug effects)
• Recovery of Function (physiology)
• Wound Healing (drug effects)