Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters.
Abstract | BACKGROUND: METHODS: RESULTS: The HFD hamsters showed significantly hyperlipidemic characteristics compared with the normal hamsters. Treatment with BBR for 10 days reduced the serum TC, TG and LDL-C levels in HFD hamsters by 44-70, 34-51 and 47-71%, respectively, and this effect was both dose- and time-dependent. Initially, a large amount of cholesterol accumulated in the hyperlipidemic hamster livers. After BBR treatment, reductions in the liver cholesterol were observed by day 3 and became significant by day 7 at both doses (P < 0.001). Meanwhile, bile cholesterol was elevated by day 3 and significantly increased at day 10 (P < 0.001). BBR promoted cholesterol excretion from the liver into the bile in hyperlipidemic hamsters but not in normal hamsters, and these results provide a link between the cholesterol-lowering effect of BBR with cholesterol excretion into the bile. CONCLUSIONS: We conclude that BBR significantly promoted the excretion of cholesterol from the liver to the bile in hyperlipidemic hamsters, which led to large decreases in the serum TC, TG and LDL-C levels. Additionally, compared with lovastatin, the BBR treatment produced no obvious side effects on the liver function.
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Authors | Xiao-Yang Li, Zhen-Xiong Zhao, Min Huang, Ru Feng, Chi-Yu He, Chao Ma, Shi-Heng Luo, Jie Fu, Bao-Ying Wen, Long Ren, Jia-Wen Shou, Fang Guo, Yangchao Chen, Xin Gao, Yan Wang, Jian-Dong Jiang |
Journal | Journal of translational medicine
(J Transl Med)
Vol. 13
Pg. 278
(Aug 27 2015)
ISSN: 1479-5876 [Electronic] England |
PMID | 26310319
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, LDL
- Dietary Fats
- RNA, Messenger
- Triglycerides
- Berberine
- Cholesterol
- Lovastatin
- gamma-Glutamyltransferase
- Aspartate Aminotransferases
- Alanine Transaminase
- Extracellular Signal-Regulated MAP Kinases
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Topics |
- Alanine Transaminase
(metabolism)
- Animals
- Aspartate Aminotransferases
(metabolism)
- Berberine
(therapeutic use)
- Cholesterol
(metabolism)
- Cholesterol, LDL
(metabolism)
- Cricetinae
- Diet, High-Fat
- Dietary Fats
- Enzyme-Linked Immunosorbent Assay
- Extracellular Signal-Regulated MAP Kinases
(metabolism)
- Hyperlipidemias
(drug therapy, metabolism)
- Lovastatin
(therapeutic use)
- Male
- Mesocricetus
- RNA, Messenger
(metabolism)
- Time Factors
- Triglycerides
(metabolism)
- gamma-Glutamyltransferase
(metabolism)
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