The Role of Hemosiderin Excision in Seizure Outcome in Cerebral Cavernous Malformation Surgery: A Systematic Review and Meta-Analysis.

Abstract

BACKGROUND AND PURPOSE:

Whether the excision of hemosiderin surrounding cerebral cavernous malformations (CCMs) is necessary to achieve a seizure-free result has been the subject of debate. Here, we report a systematic review of related literature up to Jan 1, 2015 including 594 patients to assess the effect of hemosiderin excision on seizure outcome in patients with CCMs by meta-analysis.

METHODS:

Ten studies comparing extended hemosiderin excision with only lesion resection were identified by searching the English-language literature. Meta-analyses, subgroup analyses and sensitivity analysis were conducted to determine the association between hemosiderin excision and seizure outcome after surgery.

RESULTS:

Seizure outcome was significantly improved in the patients who underwent an extended excision of the surrounding hemosiderin (OR, 0.62; 95% CI: 0.42-0.91; P = 0.01). In subgroup analysis, studies from Asia (OR, 0.42; 95% CI: 0.25-0.71; P = 0.001), male-majority (female ratio < 50%) studies (OR, 0.56; 95% CI: 0.33-0.96; P = 0.04), low occurrence rate of multiple CCMs (OR, 0.37; 95% CI: 0.20-0.71; P = 0.003), cohort studies (OR, 0.44; 95% CI: 0.28-0.68; P = 0.78), longer duration of seizure symptoms (> 1 year) before surgery (OR, 0.43; 95% CI: 0.22-0.84; P = 0.01), lesion diameter > 2 cm (OR, 0.41; 95% CI: 0.19-0.87; P = 0.02) and short-term (< 3 years) follow-up (OR, 0.48; 95% CI: 0.29-0.80; P = 0.005) tended to correlate with a significantly favorable outcome.

CONCLUSION:

Patients who underwent extended surrounding hemosiderin excision could exhibit significantly improved seizure outcomes compared to patients without hemosiderin excision. However, further well-designed prospective multiple-center RCT studies are still needed.

• Authors: Di Ruan, Xiao-Bo Yu, Sudeep Shrestha, Lin Wang, Gao Chen
• Journal: PloS one (PLoS One) Vol. 10 Issue 8 Pg. e0136619 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 26305879 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)

Chemical References

• Hemosiderin

Topics

• Asia
• Epilepsy (metabolism, physiopathology, surgery)
• Hemangioma, Cavernous, Central Nervous System (metabolism, physiopathology, surgery)
• Hemosiderin (metabolism)
• Humans
• Retrospective Studies
• Seizures (metabolism, physiopathology, surgery)
• Treatment Outcome