Abstract | BACKGROUND: METHODS: RESULTS: SL rats were 37.3 % and 15.1 % heavier than NL rats at weaning and 16-weeks-old, respectively. They had increased visceral fat mass, adult-onset insulin resistance and glucose intolerance as well as elevated serum levels of free fatty acids and triglycerides. All detectable fatty acids were elevated in the serum of SL pups at weaning compared to NL controls, and significant increases in the levels of four fatty acids ( palmitic acid, palmitoleic acid, oleic acid and arachidonic acid) persisted into adulthood. Moreover, a significantly positive correlation was identified between an insulin resistance index (HOMA-IR) and concentrations of myristic, palmitic, palmitoleic and oleic acid in serum at postnatal 16 weeks. Early postnatal overnutrition also resulted in a significant downregulation of insulin receptor substrate-1 (Irs-1), protein kinase B (Akt2) and glucose transporter 4 (Glut4) at the protein level in epididymal fat of SL rats at 16 weeks, accompanied by decreased mRNA levels for Irs-1 and Glut4. In gastrocnemius muscle, Akt2 and Glut4 mRNA and Glut4 protein levels were significantly decreased in SL rats. CONCLUSIONS: This study demonstrates that early postnatal overnutrition can have long-lasting effects on body weight and serum fatty acid profiles and can lead to impaired insulin signaling pathway in visceral white adipose tissue and skeletal muscle, which may play a major role in IR.
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Authors | Fei Bei, Jia Jia, Yi-Qun Jia, Jian-Hua Sun, Fei Liang, Zhong-Yi Yu, Wei Cai |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 14
Pg. 96
(Aug 26 2015)
ISSN: 1476-511X [Electronic] England |
PMID | 26302954
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Fatty Acids, Nonesterified
- Glucose Transporter Type 4
- Insulin
- Insulin Receptor Substrate Proteins
- Irs1 protein, rat
- Leptin
- Lipoproteins, HDL
- RNA, Messenger
- Slc2a4 protein, rat
- Triglycerides
- Akt2 protein, rat
- Proto-Oncogene Proteins c-akt
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Topics |
- Adipose Tissue, White
(metabolism)
- Animals
- Blood Glucose
(metabolism)
- Fatty Acids, Nonesterified
(blood)
- Gene Expression Regulation
- Glucose Transporter Type 4
(blood, genetics)
- Humans
- Insulin
(blood, genetics)
- Insulin Receptor Substrate Proteins
(blood, genetics)
- Insulin Resistance
- Leptin
(blood, genetics)
- Lipoproteins, HDL
(blood)
- Litter Size
- Male
- Obesity
(blood, genetics)
- Overnutrition
(blood, genetics)
- Proto-Oncogene Proteins c-akt
(blood, genetics)
- RNA, Messenger
(blood, genetics)
- Rats
- Rats, Sprague-Dawley
- Signal Transduction
- Triglycerides
(blood)
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