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Exploring diagnostic potentials of radioiodinated sennidin A in rat model of reperfused myocardial infarction.

Abstract
Non-invasive "hot spot imaging" and localization of necrotic tissue may be helpful for definitive diagnosis of myocardial viability, which is essential for clinical management of ischemic heart disease. We labeled Sennidin A (SA), a naturally occurring median dianthrone compound, with (131)I and evaluated (131)I SA as a potential necrosis-avid diagnostic tracer agent in rat model of reperfused myocardial infarction. Magnetic resonance imaging (MRI) was performed to determine the location and dimension of infarction. (131)I-SA was evaluated in rat model of 24-hour old reperfused myocardial infarction using single-photon emission computed tomography/computed tomography (SPECT/CT), biodistribution, triphenyltetrazolium chloride (TTC) histochemical staining, serial sectional autoradiography and microscopy. Gamma counting revealed high uptake and prolonged retention of (131)I SA in necrotic myocardium and fast clearance from non-targeted tissues. On SPECT/CT images, myocardial infarction was persistently visualized as well-defined hotspots over 24h, which was confirmed by perfect matches of images from post-mortem TTC staining and autoradiography. Radioactivity concentration in infarcted myocardium was over 9 times higher than that of the normal myocardium at 24h. With favorable hydrophilicity and stability, radioiodinated SA may serve as a necrosis-avid diagnostic agent for assessment of myocardial viability.
AuthorsCuihua Jiang, Meng Gao, Yue Li, Dejian Huang, Nan Yao, Yun Ji, Xuejiao Liu, Dongjian Zhang, Xiaoning Wang, Zhiqi Yin, Su Jing, Yicheng Ni, Jian Zhang
JournalInternational journal of pharmaceutics (Int J Pharm) Vol. 495 Issue 1 Pg. 31-40 (Nov 10 2015) ISSN: 1873-3476 [Electronic] Netherlands
PMID26302863 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier B.V. All rights reserved.
Chemical References
  • Anthracenes
  • Iodine Radioisotopes
  • dihydroxydianthrone
Topics
  • Animals
  • Anthracenes (metabolism, pharmacokinetics)
  • Autoradiography
  • Disease Models, Animal
  • Drug Stability
  • Hydrophobic and Hydrophilic Interactions
  • Iodine Radioisotopes (metabolism)
  • Magnetic Resonance Imaging
  • Male
  • Myocardial Reperfusion Injury (diagnostic imaging, pathology)
  • Necrosis (diagnostic imaging)
  • Radiography
  • Rats
  • Tissue Distribution
  • Tomography, Emission-Computed, Single-Photon

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