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Alpha2beta1 integrin in cancer development and chemoresistance.

Abstract
Extracellular matrix, via its receptors the integrins, has emerged as a crucial factor in cancer development. The α2β1 integrin is a major collagen receptor that is widely expressed and known to promote cell migration and control tissue homeostasis. Growing evidence suggests that it can be a key pathway in cancer. Recent studies have shown that α2β1 integrin is a regulator of cancer metastasis either by promoting or inhibiting the dissemination process of cancer cells. The α2β1 integrin signaling can also enhance tumor angiogenesis. Emerging evidence supports a role for α2β1 integrin in cancer chemoresistance especially in hematological malignancies originating from the T cell lineage. In addition, α2β1 integrin has been associated with cancer stem cells. In this review, we will discuss the complex role of α2β1 integrin in these processes. Collagen is a major matrix protein of the tumor microenvironment and thus, understanding how α2β1 integrin regulates cancer pathogenesis is likely to lead to new therapeutic approaches and agents for cancer treatment.
AuthorsDalila Naci, Kristiina Vuori, Fawzi Aoudjit
JournalSeminars in cancer biology (Semin Cancer Biol) Vol. 35 Pg. 145-53 (Dec 2015) ISSN: 1096-3650 [Electronic] England
PMID26297892 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Integrin alpha2beta1
  • Collagen
Topics
  • Animals
  • Cell Movement
  • Cell Proliferation
  • Cell Transformation, Neoplastic (genetics, metabolism)
  • Collagen (metabolism)
  • Disease Progression
  • Drug Resistance, Neoplasm (genetics)
  • Extracellular Matrix (metabolism)
  • Humans
  • Integrin alpha2beta1 (antagonists & inhibitors, genetics, metabolism)
  • Molecular Targeted Therapy
  • Neoplasm Invasiveness
  • Neoplasms (drug therapy, genetics, metabolism, pathology)
  • Neoplastic Stem Cells (metabolism)
  • Neovascularization, Pathologic (genetics, metabolism)
  • Signal Transduction

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