Reduced risk of pertussis in whole-cell compared to acellular vaccine recipients is not confounded by age or receipt of booster-doses.

Abstract

Several observational studies provide evidence that acellular pertussis vaccines (aP) are less protective against pertussis disease than highly effective whole-cell pertussis vaccines (wP), however, concerns have been raised that some of these findings may be confounded by age. By undertaking age-stratified and restricted analyses on a cohort of Australian children primed with either aP-only, wP-only or mixed pertussis vaccine schedules, we demonstrate that compared to aP the association of wP with increased protection from pertussis is not confounded by age, nor by aP booster-dose receipt.

• Authors: Sarah L Sheridan, Robert S Ware, Keith Grimwood, Stephen B Lambert
• Journal: Vaccine (Vaccine) Vol. 33 Issue 39 Pg. 5027-30 (Sep 22 2015) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 26297874 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Pertussis Vaccine
• Vaccines, Acellular
• Vaccines, Inactivated

Topics

• Age Factors
• Australia
• Child
• Child, Preschool
• Cohort Studies
• Female
• Humans
• Infant
• Male
• Pertussis Vaccine (administration & dosage, immunology)
• Vaccines, Acellular (administration & dosage, immunology)
• Vaccines, Inactivated (administration & dosage, immunology)
• Whooping Cough (epidemiology, prevention & control)