Creatinine kinase isoenzyme-MB: A simple prognostic biomarker in patients with pulmonary embolism treated with thrombolytic therapy.

Abstract

BACKGROUND:

Creatinine kinase isoenzyme-MB (CK-MB) is a biomarker for detecting myocardial injury. The aim of this study was to evaluate the association between admission CK-MB levels and in-hospital and long-term clinical outcomes in pulmonary embolism (PE) patients treated with thrombolytic tissue-plasminogen activator.

METHODS:

A total of 148 acute PE patients treated with tissue-plasminogen activator enrolled in the study. The study population was divided into 2 tertiles, based on admission CK-MB levels. The high CK-MB group (n=35) was defined as having a CK-MB level in the third tertile (>31.5 U/L), and the low group (n=113) was defined as having a level in the lower 2 tertiles (≤31.5 U/L).

RESULTS:

High CK-MB group had a higher incidence of in-hospital mortality (37.1% vs 1.7%, P<.001). Admission systolic blood pressure and tricuspid annular plane systolic excursion were lower in the high CK-MB group. In the receiver-operating characteristic curve analysis, a CK-MB value of more than 31.5 U/L yielded a sensitivity of 86.7% and specificity of 83.5% for predicting in-hospital mortality. During long-term follow-up, recurrent PE, major and minor bleeding, and mortality rates were similar in both groups.

CONCLUSION:

Creatinine kinase isoenzyme-MB is a simple, widely available, and useful biomarker for predicting adverse in-hospital clinical outcomes in PE.

• Authors: Mehmet Bozbay, Huseyin Uyarel, Sahin Avsar, Ahmet Oz, Muhammed Keskin, Veysel Ozan Tanik, Nijat Bakhshaliyev, Murat Ugur, Seckin Pehlivanoglu, Mehmet Eren
• Journal: Journal of critical care (J Crit Care) Vol. 30 Issue 6 Pg. 1179-83 (Dec 2015) ISSN: 1557-8615 [Electronic] United States
• PMID: 26296281 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Creatinine
• Creatine Kinase
• Creatine Kinase, MB Form
• Tissue Plasminogen Activator

Topics

• Aged
• Biomarkers (blood)
• Creatine Kinase (blood)
• Creatine Kinase, MB Form (blood)
• Creatinine (blood)
• Female
• Hospital Mortality
• Humans
• Incidence
• Male
• Middle Aged
• Prognosis
• Pulmonary Embolism (blood)
• Risk Factors
• Sensitivity and Specificity
• Thrombolytic Therapy
• Tissue Plasminogen Activator (metabolism)