Abstract | PURPOSE: METHODS: 22 women with PCOS and 21 age/BMI-matched women with prediabetes were subjected to a Hyperinsulinemic-euglycemic clamp and an Oral Glucose tolerance Test (OGTT). Insulin sensitivity was assessed by the glucose infusion rate during clamp (M value); insulin secretion by Insulinogenic index, Oral Disposition Index (DIo) and AUC(2h-insulin) during OGTT; and insulin clearance by the metabolic clearance rate of insulin (MCRI) during clamp. RESULTS: Women with PCOS showed significantly higher levels of AUC(2h-insulin) (p < 0.011), Insulinogenic Index (p < 0.001), DIo (p = 0.002) and significantly lower levels of AUC(2h-glucos)e (p = 0.001). No difference was found between the two groups regarding insulin sensitivity (M value). Lower levels of MCRI were found in women with PCOS [420 (IQR 227-588) vs. 743 (IQR 597-888) ml m(-2) min(-1): p < 0.001]. Furthermore, in the PCOS group, a strong independent inverse correlation was only observed between MCRI and AUC(2h-insulin) (PCOS: β:-0.878; p < 0.001; Prediabetes: β:-0.501; p = 0.019). CONCLUSIONS: Our study suggests that in normoglycemic women with PCOS there is peripheral insulin sensitivity similar to that of women with prediabetes. What sets PCOS apart is the hyperinsulinism, today still simplistically defined "compensatory"; actually this is mainly related to decreased insulin clearance whose specific causes and dynamics have yet to be clarified.
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Authors | M C Amato, R Vesco, E Vigneri, A Ciresi, C Giordano |
Journal | Journal of endocrinological investigation
(J Endocrinol Invest)
Vol. 38
Issue 12
Pg. 1319-26
(Dec 2015)
ISSN: 1720-8386 [Electronic] Italy |
PMID | 26294351
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Female
- Glucose Clamp Technique
- Humans
- Hyperinsulinism
(blood)
- Insulin
(blood)
- Insulin Resistance
- Polycystic Ovary Syndrome
(blood)
- Prediabetic State
(blood)
- Young Adult
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