Enhanced cellular uptake of nanoparticles by increasing the hydrophobicity of poly(lactic acid) through copolymerization with cell-membrane-lipid components.

Abstract	The influence of hydrophobicity on the internalization of polymeric nanoparticles (NPs) remains poorly investigated. The hydrophobicity of poly(L-lactide) was increased by copolymerization with cell-membrane-lipid components, and this significantly enhanced the uptake of NPs up to 60% in the human cervical cancer cell line in comparison to unmodified poly(L-lactide) NPs.
Authors	Mariam Samadi Moghaddam, Markus Heiny, V Prasad Shastri
Journal	Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 78 Pg. 14605-8 (Oct 07 2015) ISSN: 1364-548X [Electronic] England
PMID	26287526 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Membrane Lipids Polyesters Polymers Lactic Acid poly(lactide)
Topics	Cell Membrane (metabolism) Hydrophobic and Hydrophilic Interactions Lactic Acid (chemistry) Membrane Lipids (metabolism) Nanoparticles Polyesters Polymerization Polymers (chemistry)

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