Efficacy of diffusion-weighted magnetic resonance imaging in the evaluation of extrahepatic cholestasis-related hepatic fibrosis.

Abstract

BACKGROUND/AIM:

To investigate the efficacy of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis and staging of fibrosis induced by experimental bile duct ligation (BDL).

MATERIALS AND METHODS:

Twenty-four rats were divided randomly into four groups: control, BDL--3 days, BDL--2 weeks, and BDL--4 weeks. DWI was performed with b-values of 100 and 500 on the rats from control group at day zero, on the rats from the BDL--3 days group at the end of day 3, on the rats from the BDL--2 weeks group at the end of day 14, and on the rats from the BDL--4 weeks at the end of day 28.

RESULTS:

When fibrosis scores generated in all groups were evaluated together, a strong negative correlation was detected between fibrosis scores and apparent diffusion coefficient (ADC) values measured using b 100 and b 500. ADC values obtained using b 100 were found to be significantly higher compared to the fibrosis observed in both the BDL--2 weeks and BDL--4 weeks groups (P < 0.003 and P < 0.001, respectively).

CONCLUSION:

We think that DWI may be an alternative to liver biopsy for the diagnosis and staging of hepatic fibrosis with underlying extrahepatic cholestasis.

• Authors: Süleyman Ayvaz, Sedat Alpaslan Tuncel, Güray Can, Bekir Çağli, Turan Karaca, Selim Demirtaş, Muhammed Elmaoğlu, Mehmet Ercüment Ünlü, Mehmet Pul
• Journal: Turkish journal of medical sciences (Turk J Med Sci) Vol. 45 Issue 3 Pg. 686-93 ( 2015) ISSN: 1300-0144 [Print] Turkey
• PMID: 26281340 (Publication Type: Journal Article)

Topics

• Analysis of Variance
• Animals
• Cholestasis, Extrahepatic (complications, diagnosis)
• Diffusion Magnetic Resonance Imaging
• Disease Models, Animal
• Liver (pathology)
• Liver Cirrhosis (complications, diagnosis)
• Male
• Rats
• Rats, Sprague-Dawley
• Reproducibility of Results
• Sensitivity and Specificity