Abstract |
In recent years, the outcome of Burkitt leukemia/ lymphoma (BL) has improved significantly. Central nervous system (CNS) involvement continues to be a poor prognostic indicator. High doses of intravenous polychemotherapy, intrathecal chemotherapy, and cranio-spinal radiation therapy are used by numerous groups. Majority of patients are cured after this strategy. The next challenge is to decrease toxicities of treatment, including long-term toxicities secondary to cranio-spinal radiation therapy observed in these cured patients. Liposomal cytarabine could be a good alternative to cranio-spinal radiation therapy as already reported in acute lymphoblastic leukemia. We report here eleven patients treated in our center for BL, with liposomal cytarabine instead of cranio-spinal radiation therapy as prophylactic or curative treatment for CNS involvement. Treatment was safe with no short-term grade >3 adverse events. Moreover, no long-term side effects and no impact on outcome were observed. We conclude that LC could be a good option to decrease short/long-term side effects of cranio-spinal radiation therapy in BL and could be evaluated in a future clinical trial.
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Authors | Amandine Segot, Emmanuel Raffoux, Etienne Lengline, Catherine Thieblemont, Hervé Dombret, Nicolas Boissel, Thomas Cluzeau |
Journal | Annals of hematology
(Ann Hematol)
Vol. 94
Issue 11
Pg. 1859-63
(Nov 2015)
ISSN: 1432-0584 [Electronic] Germany |
PMID | 26280395
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimetabolites, Antineoplastic
- Liposomes
- Cytarabine
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Topics |
- Adolescent
- Adult
- Antimetabolites, Antineoplastic
(administration & dosage, adverse effects)
- Burkitt Lymphoma
(drug therapy, pathology, radiotherapy)
- Central Nervous System Neoplasms
(drug therapy, prevention & control, radiotherapy, secondary)
- Chemoprevention
(adverse effects, methods)
- Cranial Irradiation
- Cytarabine
(administration & dosage, adverse effects)
- Female
- Humans
- Liposomes
- Male
- Middle Aged
- Retrospective Studies
- Young Adult
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