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Liposomal cytarabine in prophylaxis or curative treatment of central nervous system involvement in Burkitt leukemia/lymphoma.

Abstract
In recent years, the outcome of Burkitt leukemia/lymphoma (BL) has improved significantly. Central nervous system (CNS) involvement continues to be a poor prognostic indicator. High doses of intravenous polychemotherapy, intrathecal chemotherapy, and cranio-spinal radiation therapy are used by numerous groups. Majority of patients are cured after this strategy. The next challenge is to decrease toxicities of treatment, including long-term toxicities secondary to cranio-spinal radiation therapy observed in these cured patients. Liposomal cytarabine could be a good alternative to cranio-spinal radiation therapy as already reported in acute lymphoblastic leukemia. We report here eleven patients treated in our center for BL, with liposomal cytarabine instead of cranio-spinal radiation therapy as prophylactic or curative treatment for CNS involvement. Treatment was safe with no short-term grade >3 adverse events. Moreover, no long-term side effects and no impact on outcome were observed. We conclude that LC could be a good option to decrease short/long-term side effects of cranio-spinal radiation therapy in BL and could be evaluated in a future clinical trial.
AuthorsAmandine Segot, Emmanuel Raffoux, Etienne Lengline, Catherine Thieblemont, Hervé Dombret, Nicolas Boissel, Thomas Cluzeau
JournalAnnals of hematology (Ann Hematol) Vol. 94 Issue 11 Pg. 1859-63 (Nov 2015) ISSN: 1432-0584 [Electronic] Germany
PMID26280395 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antimetabolites, Antineoplastic
  • Liposomes
  • Cytarabine
Topics
  • Adolescent
  • Adult
  • Antimetabolites, Antineoplastic (administration & dosage, adverse effects)
  • Burkitt Lymphoma (drug therapy, pathology, radiotherapy)
  • Central Nervous System Neoplasms (drug therapy, prevention & control, radiotherapy, secondary)
  • Chemoprevention (adverse effects, methods)
  • Cranial Irradiation
  • Cytarabine (administration & dosage, adverse effects)
  • Female
  • Humans
  • Liposomes
  • Male
  • Middle Aged
  • Retrospective Studies
  • Young Adult

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