Abstract | BACKGROUND: METHODS: In total, 343 premenopausal breast cancer patients treated with NAC between 2006 and 2010 were analyzed. Clinical responses were determined based on changes in tumor size measured using breast MRI. Patients with complete response or partial response were considered to have clinical response. RESULTS: After completion of NAC, 264 of 343 patients (76.9 %) developed CIOD. The clinical response rate was significantly higher in patients with CIOD than those without CIOD (65.2 vs. 51.9 %; p = 0.033). Additionally, the mean follicle-stimulating hormone (FSH) level after NAC was significantly higher in patients with clinical response (FSH 68.7 ± 34.5 vs. 59.8 ± 34.3 IU/L; p = 0.021). Multivariate analysis showed an independent association of CIOD to clinical response (OR 0.523, 95 % CI 0.297-0.918; p = 0.024). However, we observed no differences in the pathologic complete response (pCR) rate between patients with and without CIOD (8.7 vs. 6.3 %; p = 0.497). Subgroup analysis according to ER status showed that the association between CIOD and clinical response was significant in ER-positive but not ER-negative breast cancer (p = 0.025 and 0.818, respectively). CONCLUSIONS: CIOD during NAC is significantly associated with clinical response, but not pCR. Moreover, this association is only observed in ER-positive breast cancer, suggesting that the moderate difference in response to NAC is possibly a hormonal effect of chemotherapy-induced ovarian dysfunction.
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Authors | Soo Kyung Ahn, Han-Byoel Lee, Wonshik Han, Hyeong-Gon Moon, Jee Man You, Jisun Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Dong-Young Noh |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 22 Suppl 3
Pg. S391-7
(Dec 2015)
ISSN: 1534-4681 [Electronic] United States |
PMID | 26275780
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Receptors, Estrogen
- Receptors, Progesterone
- Receptor, ErbB-2
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(complications, drug therapy, metabolism, pathology)
- Chemotherapy, Adjuvant
- Female
- Follow-Up Studies
- Humans
- Immunoenzyme Techniques
- Middle Aged
- Neoadjuvant Therapy
(adverse effects)
- Neoplasm Staging
- Ovarian Diseases
(chemically induced, physiopathology)
- Prognosis
- Receptor, ErbB-2
(metabolism)
- Receptors, Estrogen
(metabolism)
- Receptors, Progesterone
(metabolism)
- Young Adult
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