Abstract | OBJECTIVE: METHODS: We enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course. RESULTS: Among the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of <1.2447 and >4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91% sensitive and 100.0% specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and <2.2, respectively, were 80% sensitive and 100% specific for the absence of infection in febrile SLE patients. CONCLUSION: The C4d/CR1 ratio is a simple and quickly determinable biomarker that enables the differentiation between infection and flare-up in febrile SLE patients at initial evaluation. Further, when combined with the CRP level, it is useful to evaluate disease activity in SLE patients with infection.
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Authors | Chen-Hung Chen, Shun-Ban Tai, Hsiang-Cheng Chen, Deng-Ho Yang, Ming-Yieh Peng, Yuh-Feng Lin |
Journal | BioMed research international
(Biomed Res Int)
Vol. 2015
Pg. 939783
( 2015)
ISSN: 2314-6141 [Electronic] United States |
PMID | 26273660
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Peptide Fragments
- Receptors, Complement
- Complement C4b
- complement C4d
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
- Complement C4b
- Diagnosis, Differential
- Erythrocytes
(metabolism)
- Female
- Fever
(blood, diagnosis)
- Humans
- Infections
(blood, diagnosis)
- Lupus Erythematosus, Systemic
(blood, diagnosis)
- Male
- Middle Aged
- Peptide Fragments
(blood)
- Receptors, Complement
(blood)
- Reproducibility of Results
- Sensitivity and Specificity
- Young Adult
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