HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Analysis of Erythrocyte C4d to Complement Receptor 1 Ratio: Use in Distinguishing between Infection and Flare-Up in Febrile Patients with Systemic Lupus Erythematosus.

AbstractOBJECTIVE:
Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare-up in febrile SLE patients.
METHODS:
We enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course.
RESULTS:
Among the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of <1.2447 and >4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91% sensitive and 100.0% specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and <2.2, respectively, were 80% sensitive and 100% specific for the absence of infection in febrile SLE patients.
CONCLUSION:
The C4d/CR1 ratio is a simple and quickly determinable biomarker that enables the differentiation between infection and flare-up in febrile SLE patients at initial evaluation. Further, when combined with the CRP level, it is useful to evaluate disease activity in SLE patients with infection.
AuthorsChen-Hung Chen, Shun-Ban Tai, Hsiang-Cheng Chen, Deng-Ho Yang, Ming-Yieh Peng, Yuh-Feng Lin
JournalBioMed research international (Biomed Res Int) Vol. 2015 Pg. 939783 ( 2015) ISSN: 2314-6141 [Electronic] United States
PMID26273660 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Peptide Fragments
  • Receptors, Complement
  • Complement C4b
  • complement C4d
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers
  • Complement C4b
  • Diagnosis, Differential
  • Erythrocytes (metabolism)
  • Female
  • Fever (blood, diagnosis)
  • Humans
  • Infections (blood, diagnosis)
  • Lupus Erythematosus, Systemic (blood, diagnosis)
  • Male
  • Middle Aged
  • Peptide Fragments (blood)
  • Receptors, Complement (blood)
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: