Staphylococcal manipulation of host immune responses.

Abstract

Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is their frequent recurrence, even when treated with antibiotics and surgical intervention, which demonstrates the bacterium's ability to manipulate innate and adaptive immune responses. In this Review, we highlight how S. aureus virulence factors inhibit complement activation, block and destroy phagocytic cells and modify host B cell and T cell responses, and we discuss how these insights might be useful for the development of novel therapies against infections with antibiotic resistant strains such as methicillin-resistant S. aureus.

• Authors: Vilasack Thammavongsa, Hwan Keun Kim, Dominique Missiakas, Olaf Schneewind
• Journal: Nature reviews. Microbiology (Nat Rev Microbiol) Vol. 13 Issue 9 Pg. 529-43 (Sep 2015) ISSN: 1740-1534 [Electronic] England
• PMID: 26272408 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Virulence Factors

Topics

• Agglutination (immunology)
• Complement Activation
• Gene Expression Regulation, Bacterial (physiology)
• Humans
• Immune Evasion
• Lymphocyte Activation
• Phagocytosis
• Staphylococcal Infections (immunology, microbiology)
• Staphylococcus aureus (physiology)
• Virulence Factors (metabolism)