Abstract | OBJECTIVE: METHODS: A comprehensive electronic search of studies published from January 1999 to October 2014 was conducted in Medline (Ovid), Embase, PubMed, Wanfang, Weipu, and CNKI. The algorithm included "TLR," " Toll-like receptor," "polymorphism," "variant," "mutation," and " cervical cancer." Seven articles, including 9 studies, were pooled using Revman 5.2 (Cochrane Collaboration, Copenhagen, Denmark). Odds ratio (OR) was used to explore the involvement of minor allele C (C vs T and CC + CT vs TT) of TLR9 (-1486T/C, rs187084) and minor allele A (A vs G and AA + AG vs GG) of TLR9 (2848G/A, rs352140) in cervical cancer risk. RESULTS:
Toll-like receptor 9 (-1486T/C, rs187084) polymorphisms were associated with an elevated risk of cervical cancer (C vs T: OR, 1.15; 95% confidence interval [CI], 1.03-1.29; CC + CT vs TT: OR, 1.30; 95% CI, 1.11-1.53). We found no significant association between TLR9 (2848G/A, rs352140) polymorphisms and cervical cancer risk (A vs G: OR, 1.15; 95% CI, 0.87-1.54; AA + AG vs GG: OR, 1.27; 95% CI, 0.75-2.17). CONCLUSIONS: This meta-analysis indicates that TLR9 (-1486T/C, rs187084)-but not TLR9 (2848G/A, rs352140)-may be a risk factor for cervical cancer.
|
Authors | Xiyan Mu, Jitong Zhao, Xin Yuan, Xitong Zhao, Kui Yao, Yingwei Liu, Xia Zhao |
Journal | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
(Int J Gynecol Cancer)
Vol. 25
Issue 7
Pg. 1173-8
(Sep 2015)
ISSN: 1525-1438 [Electronic] England |
PMID | 26270118
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- TLR9 protein, human
- Toll-Like Receptor 9
|
Topics |
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Meta-Analysis as Topic
- Polymorphism, Single Nucleotide
(genetics)
- Prognosis
- Risk Factors
- Toll-Like Receptor 9
(genetics)
- Uterine Cervical Neoplasms
(genetics)
|