Abstract | OBJECTIVES: Anti- cancer drugs are harmful to healthy persons. In recent years, occupational exposure to anti- cancer drugs has become a major concern to health care workers. To address this issue, a smear method was developed to measure widely using anti- cancer drugs depositing on the floors, safety cabinet surfaces, and tables in hospital. METHODS: Ten kinds of widely used anti- cancer drugs, paclitaxel, vincristine, docetaxel, vinorelbine, irinotecan, methotrexate, oxaliplatin, cyclophosphamide, gemcitabine and fluorouracil were collected by smearing material surfaces with methanol impregnated cellulose filter paper and/or polypropylene nonwoven. The collected anti- cancer drugs are extracted in 5 ml of 0.01% (v/v) hydrazine/ methanol solution by sonication. The extracted solution was filtered and concentrated to prepare 1ml of sample solution. Then, the anti- cancer drugs in the sample solution were simultaneously measured by LC/MS. RESULTS: The anti- cancer drugs excepting fluorouracil spread on P-tile surface were measured with recoveries of 37-101% and standard deviations (SD) of 1.8-19%. All 10 of the anti- cancer drugs on a stainless steel plate surface were measured with the recoveries of 35-111% and SD of 1.3-11%. CONCLUSIONS: Using this smear method, 9 or 10 kinds of widely used anti- cancer drug residues in hospital, possibly exposed to health care workers, were grasped.
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Authors | Takumi Takano, Shigeru Suzuki, Ikuto Tsukiyama, Hiroko Saito |
Journal | Sangyo eiseigaku zasshi = Journal of occupational health
(Sangyo Eiseigaku Zasshi)
Vol. 57
Issue 6
Pg. 275-85
( 2015)
ISSN: 1349-533X [Electronic] Japan |
PMID | 26268549
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Environmental Pollutants
- Stainless Steel
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Topics |
- Antineoplastic Agents
(analysis)
- Chromatography, Liquid
(instrumentation, methods)
- Drug Residues
(analysis)
- Environmental Pollutants
(analysis)
- Hospitals
- Mass Spectrometry
(instrumentation, methods)
- Occupational Exposure
(analysis)
- Stainless Steel
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