HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[A smear method for measuring anti-cancer drugs residues in hospitals].

AbstractOBJECTIVES:
Anti-cancer drugs are harmful to healthy persons. In recent years, occupational exposure to anti-cancer drugs has become a major concern to health care workers. To address this issue, a smear method was developed to measure widely using anti-cancer drugs depositing on the floors, safety cabinet surfaces, and tables in hospital.
METHODS:
Ten kinds of widely used anti-cancer drugs, paclitaxel, vincristine, docetaxel, vinorelbine, irinotecan, methotrexate, oxaliplatin, cyclophosphamide, gemcitabine and fluorouracil were collected by smearing material surfaces with methanol impregnated cellulose filter paper and/or polypropylene nonwoven. The collected anti-cancer drugs are extracted in 5 ml of 0.01% (v/v) hydrazine/methanol solution by sonication. The extracted solution was filtered and concentrated to prepare 1ml of sample solution. Then, the anti-cancer drugs in the sample solution were simultaneously measured by LC/MS.
RESULTS:
The anti-cancer drugs excepting fluorouracil spread on P-tile surface were measured with recoveries of 37-101% and standard deviations (SD) of 1.8-19%. All 10 of the anti-cancer drugs on a stainless steel plate surface were measured with the recoveries of 35-111% and SD of 1.3-11%.
CONCLUSIONS:
Using this smear method, 9 or 10 kinds of widely used anti-cancer drug residues in hospital, possibly exposed to health care workers, were grasped.
AuthorsTakumi Takano, Shigeru Suzuki, Ikuto Tsukiyama, Hiroko Saito
JournalSangyo eiseigaku zasshi = Journal of occupational health (Sangyo Eiseigaku Zasshi) Vol. 57 Issue 6 Pg. 275-85 ( 2015) ISSN: 1349-533X [Electronic] Japan
PMID26268549 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Environmental Pollutants
  • Stainless Steel
Topics
  • Antineoplastic Agents (analysis)
  • Chromatography, Liquid (instrumentation, methods)
  • Drug Residues (analysis)
  • Environmental Pollutants (analysis)
  • Hospitals
  • Mass Spectrometry (instrumentation, methods)
  • Occupational Exposure (analysis)
  • Stainless Steel

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: