[In vitro susceptibility of dermatophyte strains to imidazole derivatives].

Abstract

Recently, imidazole derivatives are being successfully used for the dermatomycoses. These drugs have the strongest antimycotic activity. 44 dermatophyte strains were isolated from our out-patient with dermatomycosis. Imidazole derivatives such as isoconazole, oxiconazole, bifonazole and tioconazole were studied their efficacy on these fungal agents in vitro. 4 imidazole derivatives were effective on all of the dermatophyte strains in less than or equal to 5 micrograms/ml concentration. Whereas, there were differences in Minimal Inhibition Concentration (MIC) and MIC50 values.

• Authors: M Bozkurt, S Kuştimur, M A Gürer
• Journal: Mikrobiyoloji bulteni (Mikrobiyol Bul) Vol. 23 Issue 1 Pg. 64-70 (Jan 1989) ISSN: 0374-9096 [Print] Turkey
• Vernacular Title: Dermatofit suşlarinin imidazol türevlerine karşi invitro duyarliliği.
• PMID: 2626098 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Imidazoles
• Miconazole
• oxiconazole
• isoconazole
• bifonazole
• tioconazole

Topics

• Antifungal Agents (pharmacology)
• Arthrodermataceae (drug effects)
• Dermatomycoses (drug therapy, microbiology)
• Humans
• Imidazoles (pharmacology, therapeutic use)
• Miconazole (analogs & derivatives, pharmacology)