Plasma TIMP-1 and CEA as Markers for Detection of Primary Colorectal Cancer: A Prospective Validation Study Including Symptomatic and Non-symptomatic Individuals.

Abstract

BACKGROUND/AIM:

The combination of plasma tissue inhibitor of metalloproteinases-1 (1) and CEA has been shown to have utility in early detection of colorectal cancer (2). A prospective study was performed to validate previous findings.

PATIENTS AND METHODS:

Individuals undergoing large bowel endoscopy were prospectively included (N=1965). Baseline data and co-morbidity were recorded. The primary end-point was the detection of CRC. Plasma was obtained before endoscopy and TIMP-1 and CEA levels were determined using an automated analysis platform when all samples were collected.

RESULTS:

CRC was detected in 32 individuals, 24 with colonic cancer (CC) and 8 with rectal cancer (RC). Other findings were 265 with adenomas and 889 with non-neoplastic pathology. The biomarker levels were elevated in plasma from patients with CRC, but also from patients with various co-morbidities compared to individuals without any findings at endoscopy. Univariate analysis demonstrated that both markers were significant predictors of CRC. The odds ratios (OR) for an elevated TIMP-1 level for the detection of CRC was 6.2 [95% confidence interval (CI)=3.1-13.0, p<0.0001] and for an elevated CEA level was 2.4 (95% CI=1.9-2.9, p<0.0001). A subset analysis with CC as the end-point showed an OR for TIMP-1 of 7.0 (95% CI=3.2-15.3, p<0.0001). Multivariable analysis including TIMP-1, CEA and age resulted in an OR for TIMP-1 of 2.0 (95% CI=0.7-5.2, p=0.078) and for CEA the OR was 2.2 (95% CI=1.8-2.8, p<0.0001).

CONCLUSION:

This prospective study validates a previous study testing the detection of CRC based on TIMP-1 and CEA levels (3).

• Authors: Ib Jarle Christensen, Nils Brünner, Barry Dowell, Gerard Davis, Hans Jørgen Nielsen, Graham Newstead, Denis King
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 9 Pg. 4935-41 (Sep 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26254391 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• Carcinoembryonic Antigen
• TIMP1 protein, human
• Tissue Inhibitor of Metalloproteinase-1

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (blood)
• Carcinoembryonic Antigen (blood)
• Colorectal Neoplasms (blood, enzymology)
• Endoscopy
• Female
• Humans
• Male
• Middle Aged
• Prospective Studies
• ROC Curve
• Reproducibility of Results
• Tissue Inhibitor of Metalloproteinase-1 (blood)
• Young Adult