Composition, Cytotoxic and Antimicrobial Activities of Satureja intermedia C.A.Mey Essential Oil.

Abstract

In this study, the essential oil (EO) constituents from the aerial parts of Satureja intermedia C.A.Mey were detected by GC and GC/MS. The antimicrobial activity of EO on oral pathogens and its cytotoxicity to human cancer cells were determined by the microbroth dilution method and the crystal violet staining method, respectively. Thirty-nine compounds were identified and the main EO constituents were γ-terpinene (37.1%), thymol (30.2%), p-cymene (16.2%), limonene (3.9%), α-terpinene (3.3%), myrcene (2.5%), germacrene B (1.4%), elemicine (1.1%) and carvacrol (0.5%). The S. intermedia EO showed a concentration-dependent decrease in viability of Hep-G2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) human cancer cell lines (p < 0.05). Antimicrobial screening of S. intermedia EO demonstrated slight antibacterial and antifungal activities against Streptococcus mutants, S. salivarius, Enterococcus faecalis, Staphylococcus aureus, Candida albicans and C. glabrata. Further preclinical studies are needed to assess the efficacy and safety of S. intermedia EO as a new promising anticancer agent.

• Authors: Javad Sharifi-Rad, Mehdi Sharifi-Rad, Seyedeh Mahsan Hoseini-Alfatemi, Marcello Iriti, Majid Sharifi-Rad, Marzieh Sharifi-Rad
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 16 Issue 8 Pg. 17812-25 (Aug 03 2015) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 26247936 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Antifungal Agents
• Antineoplastic Agents
• Oils, Volatile
• Terpenes

Topics

• Anti-Infective Agents (chemistry, pharmacology)
• Antifungal Agents (chemistry, pharmacology)
• Antineoplastic Agents (chemistry, pharmacology)
• Candida (drug effects)
• Hep G2 Cells
• Humans
• Lamiales (chemistry)
• MCF-7 Cells
• Oils, Volatile (chemistry, pharmacology)
• Terpenes (analysis)