Boron containing magnetic nanoparticles for neutron capture therapy--an innovative approach for specifically targeting tumors.

Abstract

The selective delivery of (10)B into the tumor tissue remains to be further improved for successful and reliable Boron Neutron Capture Therapy applications. Magnetic Drug Targeting using intraarterially administered superparamagnetic nanoparticles and external magnetic fields already exhibited convincing results in terms of highly efficient and selective drug deposition. Using the same technique for the targeted (10)B delivery is a promising new approach. Here, systematic irradiation experiments of phantom cubes containing different concentrations of boron and nanoparticles as well as varying three-dimensional arrangements have been performed.

• Authors: Rainer Tietze, Harald Unterweger, Stephan Dürr, Stefan Lyer, Lea Canella, Petra Kudejova, Franz M Wagner, Winfried Petry, Nicola Taccardi, Christoph Alexiou
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 106 Pg. 151-5 (Dec 2015) ISSN: 1872-9800 [Electronic] England
• PMID: 26242559 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015. Published by Elsevier Ltd.

Topics

• Boron Neutron Capture Therapy (methods)
• Humans
• Magnetics
• Nanoparticles
• Neoplasms (radiotherapy)