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Autoimmunity and thyrotropin level in developing thyroid malignancy.

AbstractOBJECTIVE:
Malignancies and autoimmune thyroid disease are still controversial, but recent studies prove that a long lasting thyroid disease may be linked with malignancy, e.g. papillary thyroid carcinoma in patients with Hashimoto thyroiditis. Having in mind that thyrotropin is a thyroid growth factor, the relationship between its serum values, as well as the levels of anti-peroxidase and anti-thyroglobulin antibodies and thyroid malignancy in patients with nodular thyroid goiter was examined.
PATIENTS AND METHODS:
Six-hundred-thirty-seven medical records, which included the thyroid fine-needle aspiration cytology were retrospectively evaluated. Patients were grouped regarding the levels of thyrotropin, anti-peroxidase and anti-thyroglobulin antibodies (in or out of the reference ranges) and compared with cytology findings for establishing their prognostic potential for malignancy.
RESULTS:
Elevated serum thyrotropin (≥ 4.5 mIU/L) was found in 27.3% of patients with thyroid malignancy compared with 10.8% with benign and 16.1% with unspecified cytology finding (p < 0.01). In the group of patients with malignant cytology findings 7.0% of them had elevated anti-peroxidase antibodies level, and 1.4% had anti-peroxidase antibodies level in reference range. In the group of patients with malignant cytology findings 4.2% of them had elevated anti-thyroglobulin antibodies level, and 1.4% had anti-thyroglobulin antibodies level in reference range.
CONCLUSIONS:
In patients with elevated serum thyrotropin concentration and/or chronic thyroiditis the occurrence of thyroid malignancy is increased.
AuthorsS Medenica, N Radojevic, M Stojkovic, B Nedeljkovic-Beleslin, S Savic, J Ciric, B Trbojevic, M Zarkovic
JournalEuropean review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) Vol. 19 Issue 15 Pg. 2824-9 (Aug 2015) ISSN: 2284-0729 [Electronic] Italy
PMID26241536 (Publication Type: Journal Article)
Chemical References
  • Autoantibodies
  • Biomarkers, Tumor
  • Thyrotropin
Topics
  • Adult
  • Aged
  • Autoantibodies (blood)
  • Autoimmunity (physiology)
  • Biomarkers, Tumor (blood)
  • Biopsy, Fine-Needle
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Thyroid Diseases (blood, diagnosis, immunology)
  • Thyroid Neoplasms (blood, diagnosis, immunology)
  • Thyrotropin (blood, immunology)

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