Abstract | INTRODUCTION: MATERIAL AND METHODS: RESULTS: We identified 127 patients with an adult GCT, of whom 81 (64%) had a recurrence. Twenty-five of these patients (20%) were treated with hormones, of whom 22 had measurable disease at the start of their treatment, i.e. a tumor of more than 1 cm in diameter as seen on imaging, either as a recurrence or as residual disease. The pooled objective response rate, defined as the proportion of patients whose best overall response to hormone therapy was either complete response or partial response to HT, was 18% (4/22) (95% confidence interval 6-41%). In one patient (4.5%) a complete response and in three (14%) a partial response was described. Fourteen patients (64%) had stable disease and in four patients (18%) disease was progressive. CONCLUSIONS: Although several case reports described good responses to HT in patients with a GCT, we found a response in only four of 22 patients in this relatively large consecutive series of patients.
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Authors | Hannah S van Meurs, Jacobus van der Velden, Marrije R Buist, Willemien J van Driel, Gemma G Kenter, Luc R C W van Lonkhuijzen |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 94
Issue 11
Pg. 1269-75
(Nov 2015)
ISSN: 1600-0412 [Electronic] United States |
PMID | 26230362
(Publication Type: Journal Article)
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Copyright | © 2015 Nordic Federation of Societies of Obstetrics and Gynecology. |
Chemical References |
- Antineoplastic Agents, Hormonal
- Aromatase Inhibitors
- Nitriles
- Receptors, Estrogen
- Receptors, Progesterone
- Triazoles
- Tamoxifen
- Goserelin
- Anastrozole
- Letrozole
- Megestrol Acetate
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Topics |
- Adult
- Aged
- Anastrozole
- Antineoplastic Agents, Hormonal
(therapeutic use)
- Aromatase Inhibitors
(therapeutic use)
- Chemotherapy, Adjuvant
- Disease Progression
- Disease-Free Survival
- Female
- Goserelin
(therapeutic use)
- Granulosa Cell Tumor
(metabolism, mortality, therapy)
- Humans
- Letrozole
- Megestrol Acetate
(therapeutic use)
- Middle Aged
- Nitriles
(therapeutic use)
- Ovarian Neoplasms
(metabolism, mortality, therapy)
- Ovariectomy
- Radiotherapy, Adjuvant
- Receptors, Estrogen
(metabolism)
- Receptors, Progesterone
(metabolism)
- Retrospective Studies
- Salpingectomy
- Tamoxifen
(therapeutic use)
- Triazoles
(therapeutic use)
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