Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice.

Abstract

The jaboticaba tree, Plinia trunciflora (O. Berg) Kausel, is popularly named "jabuticabeira" in Brazil and is used in folk medicine to treat diabetes and chronic inflammation of the tonsils, but studies evaluating the central effects of this species are limited. This study evaluated the antidepressant-like and antioxidant effects of P. trunciflora (PT) aqueous extract, in which five different anthocyanins were identified. PT showed significant ferric-reduction power and DPPH radical scavenging activity in vitro and reduced lipid peroxidation both in vitro and ex vivo. At the behavioural level, PT (400 and 800 mg/kg, i.p.) dose-dependently reduced immobility time in the tail suspension test in Swiss male mice. The identification of bioactive compounds accompanied by the in vitro and ex vivo antioxidant activity of PT suggests that these activities might be related to the antidepressant-like activity of P. trunciflora.

• Authors: Cassia Sacchet, Ricieri Mocelin, Adrieli Sachett, Fernanda Bevilaqua, Rafael Chitolina, Fernanda Kuhn, Aline Augusti Boligon, Margareth Linde Athayde, Walter Antonio Roman Junior, Denis Broock Rosemberg, Jacir Dal Magro, Greicy Michelle Marafiga Conterato, Angelo L Piato
• Journal: Evidence-based complementary and alternative medicine : eCAM (Evid Based Complement Alternat Med) Vol. 2015 Pg. 601503 ( 2015) ISSN: 1741-427X [Print] United States
• PMID: 26229543 (Publication Type: Journal Article)