Are obesity and metabolic syndrome associated with plasma adropin levels in children?

Abstract

Studies performed on mice suggest that adropin is a peptide hormone playing a role in metabolic homeostasis and prevention of obesity-associated insulin resistance. Our study was conducted to investigate the role of adropin in children with obesity or metabolic syndrome. The study group consisted of 70 patients, including 42 obese and 28 with metabolic syndrome, and 26 healthy volunteers. After anthropometric variables and blood pressure of all participants were measured, serum lipids were analyzed, liver USG and oral glucose tolerance test were performed, and HOMA-IR values were calculated. Plasma adropin levels were collectively analyzed from collected plasma samples. In patient and control groups, no difference was observed in the levels of adropin (327.7±124.7 vs. 344.6±208.5 ng/L, respectively). The adropin levels of metabolic syndrome, obesity, and control groups also showed no difference (316±142.3, 335.8±112.5, and 344.6±208.5 ng/L, respectively). While the adropin levels of patients with and without hepatic steatosis were 319.6±123.7 and 347.8±128.7 ng/L, respectively, patients with HOMA-IR values of <3.16 and ≥3.16 had levels 342.3±124.8 and 296.5±136.7 ng/L, respectively. Although statistically insignificant, our findings are considered to support the hypothesis suggesting a nexus between adropin and obesity and metabolic syndrome. Small sample size in our study may have prevented our results to reach a more significant level. So, long-term follow-up studies with large population are needed to enlighten the role of adropin in metabolic homeostasis.

• Authors: Celebi Kocaoglu, Muammer Buyukinan, Said Sami Erdem, Ahmet Ozel
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 28 Issue 11-12 Pg. 1293-7 (Nov 01 2015) ISSN: 2191-0251 [Electronic] Germany
• PMID: 26226125 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Blood Proteins
• Enho protein, human
• Insulin
• Intercellular Signaling Peptides and Proteins
• Peptides

Topics

• Adolescent
• Blood Glucose (metabolism)
• Blood Proteins
• Child
• Fatty Liver (blood)
• Female
• Glucose Tolerance Test
• Humans
• Insulin (blood)
• Insulin Resistance
• Intercellular Signaling Peptides and Proteins
• Male
• Metabolic Syndrome (blood)
• Obesity (blood)
• Peptides (blood)
• Risk Factors