HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Intake of Meat Mutagens and Risk of Prostate Cancer in a Cohort of U.S. Health Professionals.

AbstractBACKGROUND:
Evidence relating heterocyclic aromatic amines (HCA), associated with high-temperature cooking methods, to prostate cancer risk is inconsistent.
METHODS:
In a large U.S. cohort study, intakes of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and a meat-derived mutagenicity (MDM) index were assessed using a cooking method questionnaire administered in 1996. Until 2010, 2,770 prostate cancer cases were observed among 26,030 participants.
RESULTS:
Intake of PhIP from red meat was statistically significantly associated with total prostate cancer risk (top vs. bottom quintile HR, 1.18; 95% confidence intervals; CI, 1.03-1.35), but not other HCAs (MeIQx, 1.12; 0.98-1.27, PhIP from white meat, 1.08; 0.95-1.22, DiMeIQx, 1.09; 0.97-1.21) or MDM (1.13; 1.00-1.28). For high-grade (Gleason sum 7 with pattern 4+3 and Gleason sum 8-10, n = 483 cases) and advanced cancers (n = 281), we only observed positive associations for PhIP from red meat (top vs. bottom quintile: high grade: HR, 1.44; 95% CI, 1.04-1.98, Ptrend = 0.03; advanced: HR, 1.50; 95% CI, 0.99-2.26; Ptrend = 0.12), but associations for advanced cancers did not reach statistical significance. Observed associations remained similar after adjustment for total, unprocessed, or processed red meat intake.
CONCLUSION:
Observed positive associations between PhIP intake from red meat and prostate cancer, particularly high-grade and possibly also advanced prostate cancer, need to be confirmed in other studies.
IMPACT:
Results do not provide strong evidence that HCAs increase risk of prostate cancers.
AuthorsSabine Rohrmann, Katharina Nimptsch, Rashmi Sinha, Walter C Willett, Edward L Giovannucci, Elizabeth A Platz, Kana Wu
JournalCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 24 Issue 10 Pg. 1557-63 (Oct 2015) ISSN: 1538-7755 [Electronic] United States
PMID26224797 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
Copyright©2015 American Association for Cancer Research.
Chemical References
  • 2-amino-1-methylbenzimidazole
  • Benzimidazoles
  • Imidazoles
  • Mutagens
  • Quinoxalines
  • 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • 3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine
Topics
  • Adult
  • Aged
  • Benzimidazoles (adverse effects)
  • Cooking
  • Feeding Behavior
  • Follow-Up Studies
  • Health Personnel (statistics & numerical data)
  • Humans
  • Imidazoles (adverse effects)
  • Incidence
  • Male
  • Meat (analysis)
  • Middle Aged
  • Mutagens (adverse effects, chemistry)
  • Prostatic Neoplasms (epidemiology, etiology)
  • Quinoxalines (adverse effects)
  • Reproducibility of Results
  • Retrospective Studies
  • Risk Assessment (methods)
  • Risk Factors
  • Surveys and Questionnaires
  • United States (epidemiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: