Efficacy of weekly docetaxel in locally advanced cardiac angiosarcoma.

Abstract

BACKGROUND:

Primary cardiac angiosarcoma is extremely aggressive; however, it is often misdiagnosed because of its rarity. For locally advanced tumors, doxorubicin-based chemotherapy regimens are the standard of treatment, even if the gain in term of progression-free survival is limited and is no longer than 5 months.

CASE PRESENTATION:

We report the case of a Caucasian 23-year-old man with locally advanced cardiac angiosarcoma who underwent radical surgical resection after a prolonged response to weekly docetaxel and complementary radiotherapy.

CONCLUSION:

Combined treatment with weekly docetaxel and radiotherapy may be a valid alternative for the treatment of locally advanced cardiac angiosarcoma; the combination can lead to radical surgical resections, avoiding the cumulative cardiotoxicity of antracycline-based regimens.

• Authors: Santino Minichillo, Maria Abbondanza Pantaleo, Margherita Nannini, Fabio Coccolo, Lidia Gatto, Guido Biasco, Giovanni Brandi
• Journal: BMC research notes (BMC Res Notes) Vol. 8 Pg. 325 (Jul 30 2015) ISSN: 1756-0500 [Electronic] England
• PMID: 26223870 (Publication Type: Case Reports, Journal Article)

Chemical References

• Taxoids
• Docetaxel

Topics

• Combined Modality Therapy (methods)
• Docetaxel
• Fatal Outcome
• Gamma Rays (therapeutic use)
• Heart Neoplasms (diagnostic imaging, pathology, surgery, therapy)
• Hemangiosarcoma (diagnostic imaging, pathology, surgery, therapy)
• Humans
• Male
• Taxoids (therapeutic use)
• Treatment Outcome
• Ultrasonography
• Young Adult