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The utility of pregnancy-associated plasma protein A for determination of prognosis in a cohort of patients with coronary artery disease.

AbstractBACKGROUND:
Pregnancy-associated plasma protein-A (PAPP-A) is discussed as a biomarker representing unstable plaques in coronary artery disease (CAD).
METHODS:
In this study 927 patients with CAD (534 with stable angina and 393 with acute coronary syndrome [ACS]) and 217 patients without CAD and measured PAPP-A levels were included. Follow-up for a median of 5 years was documented.
RESULTS:
Rising quartiles of PAPP-A concentration had a higher cardiovascular mortality in the overall cohort of patients with CAD (p = 0.002) and the cohort with ACS (p = 0.01). Patients with suspected ACS below the LOD for troponin I but elevated PAPP-A levels had an increased cardiovascular mortality. A cut-off of 11.4 IU/l identified patients with a higher mortality during follow-up.
CONCLUSION:
Rising PAPP-A levels are prognostic in patients with CAD. PAPP-A levels were especially predictive in ACS patients with troponin below 10% CV of the 99 th percentile for cardiovascular mortality.
AuthorsElvin Zengin, Christoph Sinning, Tanja Zeller, Hans-J Rupprecht, Renate B Schnabel, Karl-J Lackner, Stefan Blankenberg, Dirk Westermann, Christoph Bickel, AtheroGene Study investigators
JournalBiomarkers in medicine (Biomark Med) Vol. 9 Issue 8 Pg. 731-41 ( 2015) ISSN: 1752-0371 [Electronic] England
PMID26223809 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Troponin I
  • Pregnancy-Associated Plasma Protein-A
Topics
  • Aged
  • Biomarkers (blood)
  • Cohort Studies
  • Coronary Artery Disease (blood, diagnosis)
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Pregnancy-Associated Plasma Protein-A (metabolism)
  • Prognosis
  • ROC Curve
  • Risk Factors
  • Troponin I (blood)

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