Abstract | BACKGROUND: METHODS: In this study 927 patients with CAD (534 with stable angina and 393 with acute coronary syndrome [ACS]) and 217 patients without CAD and measured PAPP-A levels were included. Follow-up for a median of 5 years was documented. RESULTS: Rising quartiles of PAPP-A concentration had a higher cardiovascular mortality in the overall cohort of patients with CAD (p = 0.002) and the cohort with ACS (p = 0.01). Patients with suspected ACS below the LOD for troponin I but elevated PAPP-A levels had an increased cardiovascular mortality. A cut-off of 11.4 IU/l identified patients with a higher mortality during follow-up. CONCLUSION: Rising PAPP-A levels are prognostic in patients with CAD. PAPP-A levels were especially predictive in ACS patients with troponin below 10% CV of the 99 th percentile for cardiovascular mortality.
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Authors | Elvin Zengin, Christoph Sinning, Tanja Zeller, Hans-J Rupprecht, Renate B Schnabel, Karl-J Lackner, Stefan Blankenberg, Dirk Westermann, Christoph Bickel, AtheroGene Study investigators |
Journal | Biomarkers in medicine
(Biomark Med)
Vol. 9
Issue 8
Pg. 731-41
( 2015)
ISSN: 1752-0371 [Electronic] England |
PMID | 26223809
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Troponin I
- Pregnancy-Associated Plasma Protein-A
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Topics |
- Aged
- Biomarkers
(blood)
- Cohort Studies
- Coronary Artery Disease
(blood, diagnosis)
- Female
- Follow-Up Studies
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Pregnancy-Associated Plasma Protein-A
(metabolism)
- Prognosis
- ROC Curve
- Risk Factors
- Troponin I
(blood)
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