Abstract | OBJECTIVES: Remote ischemic perconditioning is the newest technique used to lessen ischemia/reperfusion injury. However, its effect in hypertensive animals has not been investigated. This study aimed to examine the effect of remote ischemic perconditioning in spontaneously hypertensive rats and determine whether chronic treatment with Olmesartan could influence the effect of remote ischemic perconditioning. METHODS: RESULTS: CONCLUSION: The results indicate that (1) the protective effect of remote ischemic perconditioning is lost in vehicle-treated rats and that chronic treatment with Olmesartan restores the protective effect of remote ischemic perconditioning; (2) chronic treatment with Olmesartan down-regulates HIF-1α, miR-21 and miR-210 expression and reduces hypertrophy, thereby limiting ischemia/reperfusion injury; and (3) recovery of the protective effect of remote ischemic perconditioning is related to the up-regulation of HIF-1α, miR-21 and miR-210 expression.
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Authors | Xin Lu, Yan-Wen Bi, Ke-Biao Chen |
Journal | Clinics (Sao Paulo, Brazil)
(Clinics (Sao Paulo))
Vol. 70
Issue 7
Pg. 500-7
(Jul 2015)
ISSN: 1980-5322 [Electronic] United States |
PMID | 26222820
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Imidazoles
- Tetrazoles
- olmesartan
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Topics |
- Angiotensin II Type 1 Receptor Blockers
(pharmacology)
- Animals
- Disease Models, Animal
- Imidazoles
(pharmacology)
- Ischemic Preconditioning, Myocardial
- Myocardial Reperfusion Injury
(prevention & control)
- Random Allocation
- Rats
- Rats, Inbred SHR
- Tetrazoles
(pharmacology)
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