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A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery.

Abstract
Polymeric nanoparticles have been widely used as nano-drug delivery systems in preclinical and clinical trials for cancer therapy, and these systems usually need to be sterically stabilized by poly(ethylene glycol) (PEG) to maintain stability and avoid rapid clearance by the immune system. Recently, zwitterionic materials have been demonstrated to be potential alternatives to the classic PEG. Herein, we developed two drug delivery systems stabilized by zwitterionic polyphosphoesters. These nanoparticles showed favourable stability and anti-protein absorption ability in vitro. Meanwhile, as drug carriers, these zwitterionic polyphosphoester-stabilized nanoparticles significantly prolonged drug circulation half-lives and increased drug accumulation in tumors, which was comparable to PEG-stabilized nanoparticles. Systemic delivery of doxorubicin (DOX) by zwitterionic polyphosphoester-stabilized nanoparticles significantly inhibited tumor growth in a MDA-MB-231 tumor model, suggesting the potential of zwitterionic polyphosphoester-based nanoparticles in anticancer drug delivery.
AuthorsRong Sun, Xiao-Jiao Du, Chun-Yang Sun, Song Shen, Yang Liu, Xian-Zhu Yang, Yan Bao, Yan-Hua Zhu, Jun Wang
JournalBiomaterials science (Biomater Sci) Vol. 3 Issue 7 Pg. 1105-13 (Jul 2015) ISSN: 2047-4849 [Electronic] England
PMID26221944 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amino Acid Transport Systems, Neutral
  • Drug Carriers
  • Polymers
  • Polyethylene Glycols
  • Doxorubicin
Topics
  • Amino Acid Transport Systems, Neutral (chemistry, pharmacokinetics)
  • Cell Line, Tumor
  • Doxorubicin (chemistry, therapeutic use)
  • Drug Carriers
  • Drug Delivery Systems (methods)
  • Humans
  • Hydrogen-Ion Concentration
  • Nanoparticles (chemistry)
  • Polyethylene Glycols (chemistry)
  • Polymers (chemistry)

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