Abstract | PURPOSE: MATERIALS AND METHODS: A total of 40 male Wistar-Albino rats at age 3 weeks were divided into 5 groups. In the sham operated group the right testis was sutured and orchiectomy was performed 24 hours later. In groups 2 to 5 orchiectomy was performed 24 hours later following testicular torsion. In groups 3 and 4 unloaded and growth hormone loaded gelatin films, respectively, were sutured on the contralateral testes. In group 5 systemic growth hormone was administered for 7 days. Five weeks later each rat was cohabited with 2 female rats and the left testes were removed for evaluation. Mean seminiferous tubular diameter, mean testicular biopsy score and the mean haploid cell percentage were calculated. Mating studies were performed and fertility parameters were assayed. RESULTS: Mean seminiferous tubular diameter, mean testicular biopsy score and the mean haploid cell percentage of the contralateral testes were significantly decreased in the control and gelatin groups compared with the other groups. There was no difference between the local and systemic growth hormone groups regarding the haploid cell percentage. There were no differences between the groups in mean fetus numbers, mating or fertility and fecundity indexes except in the gelatin group, in which the mean fetus number was significantly lower. CONCLUSIONS:
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Authors | Ufuk Ates, Gulnur Gollu, Meltem Bingol-Kologlu, Deniz Billur, Gonul Kucuk, Nihan Oruklu, Umit Bagrıacik, Nesrin Hasırcı, Hüseyin Dindar |
Journal | The Journal of urology
(J Urol)
Vol. 194
Issue 6
Pg. 1816-22
(Dec 2015)
ISSN: 1527-3792 [Electronic] United States |
PMID | 26220218
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Administration, Topical
- Animals
- Female
- Fertility
(drug effects)
- Germ Cells
(drug effects, pathology)
- Growth Hormone
(pharmacology)
- Male
- Orchiectomy
- Pregnancy
- Rats
- Rats, Wistar
- Seminiferous Tubules
(drug effects, pathology)
- Sexual Maturation
(drug effects)
- Spermatic Cord Torsion
(pathology)
- Testis
(drug effects, pathology)
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