Presence of Gyriform Air Predicts Unfavorable Outcome in Venous Catheter-Related Cerebral Air Embolism.

Abstract

BACKGROUND:

This study aimed to investigate the clinical predictors of unfavorable prognosis in patients with venous catheter-related cerebral air embolism.

METHODS:

An extensive review of English literature was performed to obtain reports on cerebral air embolism published between January 1982 and July 2014 through PubMed, Journal at Ovid, and Web of Science using the Mesh terms and keywords "cerebral air embolism" and "cerebral gas embolism." Reports not fulfilling the diagnosis of cerebral air embolism and iterant articles were excluded. Demographics, clinical manifestations, and imaging findings were recorded. The air distribution on initial brain computed tomography (CT) was recorded as gyriform air (GF), cavernous sinus bubble, venous sinus bubble, and parenchymal and subarachnoid bubble. The enrolled subjects were further divided into favorable and unfavorable outcome groups for analyses.

RESULTS:

Of the 33 cases enrolled, 31 had documented follow-up outcomes, including 14 with favorable and 17 with unfavorable prognoses. Patients with unfavorable outcome had older onset age (67.5 ± 15.8 versus 46.7 ± 17.0 years, P < .001), higher frequency of GF on brain CT (58.8% versus 0%, P < .01), initial consciousness disturbance (100% versus 42.9%, P < .001), and hemiparesis (100% versus 42.9%, P < .001), but lower frequency of cardiopulmonary symptoms (5.9% versus 64.3%, P < .01). In patients with central venous catheter-related cerebral air embolism, the retrograde mechanism had a tendency for worse outcomes (43.8% versus 0%, P = .023).

CONCLUSIONS:

In patients with venous catheter-related cerebral air embolism, the presence of GF on brain CT imaging, old age, initial conscious disturbance, and hemiparesis may predict unfavorable outcomes.

• Authors: Chih-Kuang Cheng, Ting-Yu Chang, Chi-Hung Liu, Chien-Hung Chang, Kuo-Lun Huang, Shy-Chyi Chin, Hsiu-Chuan Wu, Yeu-Jhy Chang, Tsong-Hai Lee
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 24 Issue 10 Pg. 2189-95 (Oct 2015) ISSN: 1532-8511 [Electronic] United States
• PMID: 26219843 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Aging
• Brain (diagnostic imaging, pathology)
• Catheterization, Central Venous (adverse effects)
• Consciousness Disorders (etiology)
• Databases, Bibliographic (statistics & numerical data)
• Embolism, Air (complications, diagnosis, etiology, therapy)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Paresis (etiology)
• Retrospective Studies
• Tomography, X-Ray Computed