Abstract | BACKGROUND AND PURPOSE: Growth differentiation factor-15 (GDF-15) and soluble (s)ST2 are markers of cardiac and vascular stress. We investigated the associations between circulating concentrations of these biomarkers and incident stroke and subclinical vascular brain injury in a sample from the Framingham Offspring cohort. METHODS: We followed 3374 stroke- and dementia-free individuals (mean age, 59.0±9.7 years; 53% women) attending the Framingham Offspring sixth examination cycle 11.8±3.0 years for incident stroke. A subsample of 2463 individuals underwent brain magnetic resonance imaging and neuropsychological testing ≈4.0±1.7 years after the sixth examination. RESULTS: After adjustment for traditional cardiovascular risk factors, B-type natriuretic peptide, high-sensitivity C-reactive protein, and urine albumin levels, higher stress biomarker levels were associated cross-sectionally with lower brain volumes (β coefficients for intracranial volume comparing fourth [Q4] versus first biomarker [Q1] quartiles: -0.71% for GDF-15; P=0.002 and 0.47% for sST2; P=0.02) and worse performance on the visual reproduction test (β coefficients for Q4 versus Q1: -0.62 for GDF-15; P=0.009 and -0.40 for sST2; P=0.04). Higher GDF-15 concentrations were also associated with greater log-transformed white-matter hyperintensity volumes (β for Q4 versus Q1=0.19; P=0.01). Prospectively, a total of 203 (6%) individuals developed incident stroke/ transient ischemic attack during follow-up. After multivariable adjustment, sST2 remained significantly associated with stroke/ transient ischemic attack, hazard ratio for Q4 versus Q1 of 1.76, 95% confidence interval of 1.06 to 2.92, and P=0.03. CONCLUSIONS:
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Authors | Charlotte Andersson, Sarah R Preis, Alexa Beiser, Charles DeCarli, Kai C Wollert, Thomas J Wang, James L Januzzi Jr, Ramachandran S Vasan, Sudha Seshadri |
Journal | Stroke
(Stroke)
Vol. 46
Issue 9
Pg. 2568-75
(Sep 2015)
ISSN: 1524-4628 [Electronic] United States |
PMID | 26219649
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 American Heart Association, Inc. |
Chemical References |
- Biomarkers
- Growth Differentiation Factor 15
- IL1RL1 protein, human
- Interleukin-1 Receptor-Like 1 Protein
- Receptors, Cell Surface
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Topics |
- Aged
- Biomarkers
(blood)
- Brain
(pathology, physiopathology)
- Cerebrovascular Trauma
(blood)
- Cognition Disorders
(blood)
- Cross-Sectional Studies
- Female
- Growth Differentiation Factor 15
(blood)
- Humans
- Interleukin-1 Receptor-Like 1 Protein
- Ischemic Attack, Transient
(blood)
- Longitudinal Studies
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Receptors, Cell Surface
(blood)
- Stroke
(blood)
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