Effect of Pyrrolobenzimidazole Derivative RU-792 on Experimental Brain Ischemia.

Abstract

Compound RU-792 showed pronounced anti-ischemic activity and improved survival of rats with brain ischemia by normalizing parameters of spontaneous motor activity and reducing neurological deficit within 3 post-operative days being superior to the reference drug mexidol by this parameter. RU-792 inhibited the formation of conjugated dienes and malonic dialdehyde and increased activity of the antioxidant enzyme glutathione peroxidase thereby modulating the parameters of free radical oxidation in rats subjected to ischemia more effectively than mexidol.

• Authors: V A Kosolapov, D V Sorotskii, A A Spasov, V A Anisimova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 159 Issue 3 Pg. 372-5 (Jul 2015) ISSN: 1573-8221 [Electronic] United States
• PMID: 26212813 (Publication Type: Journal Article)

Chemical References

• Benzimidazoles
• Picolines
• Pyrroles
• RU-792
• emoxypine succinate
• Glutathione Peroxidase

Topics

• Animals
• Benzimidazoles (therapeutic use)
• Brain Ischemia (drug therapy, enzymology)
• Glutathione Peroxidase (metabolism)
• Lipid Peroxidation (drug effects)
• Male
• Oxidation-Reduction (drug effects)
• Picolines (therapeutic use)
• Pyrroles (therapeutic use)
• Rats