Abstract | BACKGROUND: METHODS: We conducted a review of the United Network for Organ Sharing database from 2005 to 2013 for patients aged 65 years or more with idiopathic pulmonary fibrosis. A 1:1 nearest-neighbor propensity match was utilized to determine differences in survival by transplant procedure type (SOLT versus BOLT). Logistic regression modeling taking into account interaction terms between prespecified variables and the type of transplant was utilized to determine variables that altered the survival outcomes associated with SOLT versus BOLT. RESULTS: Of 1,564 patients who met study criteria, 521 (33.3%) received BOLT. After propensity matching 498 BOLT recipients to 498 SOLT recipients, BOLT was associated with a significantly improved 5-year survival (48.7% versus 35.2%, p < 0.01). However, the mortality hazard associated with BOLT varied from a nonsignificant reduction in survival within 3 months after transplant (hazard ratio 1.24, 95% confidence interval: 0.80 to 1.93) to a significant survival benefit for patients who survived beyond 1 year (hazard ratio 0.64, 95% confidence interval: 0.47 to 0.86). Functional status was also found to be a significant predictor of the survival benefit associated with BOLT. CONCLUSIONS:
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Authors | Brian C Gulack, Asvin M Ganapathi, Paul J Speicher, James M Meza, Sameer A Hirji, Laurie D Snyder, R Duane Davis, Matthew G Hartwig |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 100
Issue 5
Pg. 1826-33
(Nov 2015)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 26210946
(Publication Type: Clinical Study, Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Female
- Humans
- Idiopathic Pulmonary Fibrosis
(surgery)
- Lung Transplantation
(methods, standards)
- Male
- Retrospective Studies
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