Eosinophilia in Pulmonary Disorders.

Abstract

Lung disease associated with marked peripheral blood eosinophilia is unusual and nearly always clinically significant. Once recognized, it is generally easy to manage, albeit with long-term systemic corticosteroids. A failure to respond to oral steroids in the context of good compliance suggests a malignant cause for the eosinophilia. An important development is the introduction of antieosinophil therapies, particularly those directed against the interleukin 5 pathway, which is hoped to provide benefit in the full spectrum of eosinophilic lung disease as well as asthma, reducing the burden of side effects and resultant comorbidities.

• Authors: Kerry Woolnough, Andrew J Wardlaw
• Journal: Immunology and allergy clinics of North America (Immunol Allergy Clin North Am) Vol. 35 Issue 3 Pg. 477-92 (Aug 2015) ISSN: 1557-8607 [Electronic] United States
• PMID: 26209896 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Adrenal Cortex Hormones

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Animals
• Asthma (diagnosis, pathology)
• Cell Movement
• Churg-Strauss Syndrome (diagnosis, pathology)
• Eosinophils (cytology, metabolism)
• Granulomatosis with Polyangiitis (diagnosis, pathology)
• Helminthiasis (parasitology, pathology)
• Helminths (pathogenicity)
• Humans
• Hypereosinophilic Syndrome (diagnosis, pathology)
• Lung (cytology, pathology)
• Lung Diseases, Parasitic (diagnosis, parasitology, pathology)
• Pulmonary Eosinophilia (diagnosis, pathology)
• Sputum (cytology)