HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Quercetin intraperitoneal administration ameliorates lipopolysaccharide-induced systemic inflammation in mice.

AbstractAIMS:
The purpose of this study was to unravel pharmacological effects of quercetin (Q) on systemic inflammation in septic mice, and compare it to quercetin-3-glucuronide (Q3G), a major metabolite of Q.
MAIN METHODS:
A suitable sepsis mouse model was first established using lipopolysaccharide (LPS) injected intraperitoneally (i.p.). Q or Q3G was administered i.p. to septic mice in a prophylactic or therapeutic manner. Pro-inflammatory (TNF-α, IL-1β and IL-6) and anti-inflammatory (IL-10) cytokine secretion profiles by peritoneal macrophages of the mice were measured using ELISA.
KEY FINDINGS:
Mice which received 8mg/kg BW LPS i.p. for 12h resulted in intermediate systemic inflammation, suggesting a useful mild septic mouse model. At non-toxic doses, Q or Q3G (0.06 or 0.15μmol/mouse) i.p. injected in a prophylactic manner significantly (P<0.05) increased anti-inflammatory IL-10 secretions by peritoneal macrophages of the LPS-induced septic mice. Q, but not Q3G, i.p. injected in a therapeutic manner significantly (P<0.05) increased IL-10 secretions by peritoneal macrophages of the septic mice.
SIGNIFICANCE:
Our data suggest that Q, but not Q3G, has pharmacological effects to ameliorate systemic inflammation. These results are the first to show that Q has potent potential against sepsis in both prophylactic and therapeutic manners in vivo.
AuthorsYi-Ru Liao, Jin-Yuarn Lin
JournalLife sciences (Life Sci) Vol. 137 Pg. 89-97 (Sep 15 2015) ISSN: 1879-0631 [Electronic] Netherlands
PMID26209141 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Inflammation Mediators
  • Lipopolysaccharides
  • Quercetin
Topics
  • Animals
  • Anti-Inflammatory Agents (administration & dosage, pharmacology, therapeutic use)
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Female
  • Inflammation (complications, drug therapy, immunology, prevention & control)
  • Inflammation Mediators (metabolism)
  • Injections, Intraperitoneal
  • Lipopolysaccharides (immunology)
  • Macrophages (drug effects, metabolism)
  • Mice
  • Quercetin (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
  • Sepsis (complications, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: