HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Insights into the clinical value of cyclin-dependent kinase 5 in glioma: a retrospective study.

AbstractBACKGROUND:
Previous studies suggested that expression of cyclin-dependent kinase 5 (CDK5) may promote the migration and invasion of human glioma cells. In this study, we aimed to evaluate the clinical value of CDK5 in different grades of glioma in relation to Ki-67 labeling index (LI).
METHODS:
We firstly assessed by immunohistochemistry the expression of CDK5 in 152 glioma tissues and 16 normal brain tissues and further explored the relationship between CDK5 expression and other clinical features.
RESULTS:
The positive ratio of CDK5 in gliomas (57.2%) was higher than that in normal brain tissues (12.5%, P=0.001). Difference of CDK5 expression among four World Health Organization (WHO) grades was statistically significant (P=0.001). The significant differences of CDK5 expression were also observed between WHO I glioma (34.8%) and WHO III glioma (62.5%), as well as WHO IV glioma (82.8%; P=0.026, P<0.001, respectively). Furthermore, Spearman's rank correlation confirmed that CDK5 was positively correlated with the pathological grade of glioma (r=0.831, P<0.001). The CDK5 expression was also positively correlated with Ki-67 LI (r=0.347, P<0.001).
CONCLUSIONS:
The current result suggests that CDK5 may play an essential role in the tumorigenesis and aggressiveness of gliomas.
AuthorsRuan Yushan, Chen Wenjie, Huang Suning, Dang Yiwu, Zhong Tengfei, Wickramaarachchi Mihiranganee Madushi, Luo Feifei, Zhang Changwen, Wen Xin, Gopaul Roodrajeetsing, Li Zuyun, Chen Gang
JournalWorld journal of surgical oncology (World J Surg Oncol) Vol. 13 Pg. 223 (Jul 25 2015) ISSN: 1477-7819 [Electronic] England
PMID26205145 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • Cyclin-Dependent Kinase 5
  • CDK5 protein, human
Topics
  • Adolescent
  • Adult
  • Aged
  • Biomarkers, Tumor (metabolism)
  • Brain (metabolism, pathology)
  • Brain Neoplasms (metabolism, pathology)
  • Case-Control Studies
  • Child
  • Cyclin-Dependent Kinase 5 (metabolism)
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Glioma (metabolism, pathology)
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Prognosis
  • Retrospective Studies
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: