[Chemoprevention for Familial Adenomatous Polyposis].

Abstract

Colorectal cancer (CRC) is the second most common cancer in Japan. Primary cancer prevention is especially desired for hereditary CRC patients, owing to the high incidence of cancer in these patients. Prophylactic total proctocolectomy is generally accepted for young FAP patients; however, this procedure may reduce their QOL. If we could obtain effective chemopreventive drugs for FAP patients, prophylactic surgery could be postponed until the patients are older, or be avoided altogether. Thus, such drugs would bring large benefits to FAP patients. In this review, the history of chemopreventive drug development for FAP and the future prospects of chemopreventive drugs are described.

• Authors: Nagahide Matsubara, Kazuo Tamura, Naohiro Tomita
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 6 Pg. 699-703 (Jun 2015) ISSN: 0385-0684 [Print] Japan
• PMID: 26199240 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Cyclooxygenase 2 Inhibitors
• Drug Combinations
• Polyamines

Topics

• Adenomatous Polyposis Coli (prevention & control)
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Chemoprevention
• Cyclooxygenase 2 Inhibitors (therapeutic use)
• Drug Combinations
• Humans
• Polyamines (metabolism, therapeutic use)