Abstract | STUDY OBJECTIVES: METHODS: Patients with minor stroke or TIA were recruited. Level 3 diagnostic sleep testing was used to diagnose OSA and quantify nocturnal hypoxemia. Significant OSA was defined as respiratory disturbance index ≥ 15, and nocturnal hypoxemia was defined as oxyhemoglobin saturation < 90% for ≥ 12% of total monitoring time. WMH were assessed and quantified on FLAIR MRI. The volume of WMH was compared between those with and without significant OSA and between those with and without nocturnal hypoxemia. RESULTS: One hundred nine patients were included. Thirty-four (31%) had OSA and 37 (34%) had nocturnal hypoxemia. Total WMH volume was significantly greater in the OSA than in the non-OSA groups (p = 0.04). WMH volume was also significantly higher in the hypoxic than the non-hypoxic groups (p = 0.001). Mutivariable analysis with adjustment for age, hypertension, and diabetes showed that nocturnal hypoxemia was independently associated with WMH volume (p = 0.03) but OSA was not (p = 0.29). CONCLUSIONS: We conclude that nocturnal hypoxemia, predominantly related to OSA, is independently associated with WMH in patients who present with minor ischemic stroke and TIA and may contribute to its pathogenesis.
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Authors | Shiel K Patel, Patrick J Hanly, Eric E Smith, Wesley Chan, Shelagh B Coutts |
Journal | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
(J Clin Sleep Med)
Vol. 11
Issue 12
Pg. 1417-24
(Dec 15 2015)
ISSN: 1550-9397 [Electronic] United States |
PMID | 26194729
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 American Academy of Sleep Medicine. |
Topics |
- Female
- Humans
- Hypoxia
(complications, physiopathology)
- Ischemic Attack, Transient
(classification)
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Stroke
(complications)
- White Matter
(physiopathology)
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