Epstein-Barr virus-positive inflammatory pseudotumor of the spleen managed with laparoscopic splenectomy.

Abstract

We report a case of Epstein-Barr virus (EBV)-positive splenic inflammatory pseudotumor treated by laparoscopic splenectomy. A 66-year-old female without symptoms was found to have a solitary, avascular, solid tumor of the spleen by contrast-enhanced computed tomography. The tumor was compatible with a primary tumor of the spleen. A benign splenic tumor was the most likely diagnosis, but malignant lymphoma could not be ruled out because the serum-soluble interleukin-2 receptor (sIL-2R) level was elevated. Laparoscopic splenectomy was performed to enable a definite diagnosis. Removal of the whole spleen without injury was possible. Possible contamination of the extirpation orifice by cancer cells was carefully prevented by enclosing the spleen in a plastic bag. Histopathological examination showed the tumor to be an EBV-positive inflammatory pseudotumor. To the best of our knowledge, this is only the second report of an EBV-positive splenic inflammatory pseudotumor with an increased serum sIL-2R level. Although EBV-positive inflammatory pseudotumors have been reported to recur, no sign of recurrence has been detected in the present case in the 17 months following splenectomy.

• Authors: Norihito Ise, Hideaki Miyazawa, Seiji Satoh, Masatake Iida, Hiroshi Uchinami, Makoto Kume, Masato Yoshioka, Hiroshi Nanjo, Yuzo Yamamoto
• Journal: Clinical journal of gastroenterology (Clin J Gastroenterol) Vol. 1 Issue 4 Pg. 164-167 (Dec 2008) ISSN: 1865-7257 [Print] Japan
• PMID: 26193697 (Publication Type: Journal Article)