Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus.

Abstract

Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response to the diabetic milieu. A significant reduction of serum IGF-I levels was observed in patients with type 1 diabetes mellitus (T1DM). Inversely, considerably increased serum levels of IGF-I and IGFBP-3 levels were detected in individuals with glucose intolerance including T2DM. Recently, several prospective studies indicated that baseline levels of IGF-I and IGFBPs are associated with the development of diabetes. These findings suggest that disturbances in insulin and IGF-I-IGFBP axis can affect the development of glucose intolerance including diabetes.

• Authors: Min Sun Kim, Dae-Yeol Lee
• Journal: Annals of pediatric endocrinology & metabolism (Ann Pediatr Endocrinol Metab) Vol. 20 Issue 2 Pg. 69-73 (Jun 2015) ISSN: 2287-1012 [Print] Korea (South)
• PMID: 26191509 (Publication Type: Journal Article, Review)