HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Small-volume resuscitation with hypertonic saline solution in hypovolemic cats.

Abstract
We evaluated the hemodynamic effects of IV and intraaortic (aortic root) administration of 7.5% NaCl solution on hemodynamics in anesthetized cats with severe hypovolemia. Hypovolemic shock was induced by exsanguinating cats to a mean arterial blood pressure of 50 mm of Hg, which was maintained for 30 minutes prior to treatment. Shed blood volume was 38.4 +/- 2.1 ml/kg of body weight. The cats were treated with a small volume (4 ml/kg) of 0.9% NaCl solution IV, 7.5% NaCl solution IV, or 7.5% NaCl solution administered into the aortic root. The IV administration of 0.9% NaCl solution did not improve hemodynamics. The IV administration of 7.5% NaCl solution induced rapid restoration of arterial blood pressure, aortic blood flow, and cardiac contractility. Total peripheral vascular resistance decreased. The administration of 7.5% NaCl solution into the aortic root induced a further deterioration in hemodynamics resulting in death in 3 cats and a marked improvement in hemodynamics similar to that observed after IV administration of 7.5% NaCl solution in 2 cats. The duration of the beneficial hemodynamic effects after IV or intra-aortic administration of 7.5% NaCl solution did not exceed 60 minutes. Results of these studies suggested that either the IV or intra-aortic administration of 7.5% NaCl solution in cats can induce beneficial hemodynamic effects that may be of value in the field resuscitation of hypovolemic patients.
AuthorsW W Muir 3rd, J Sally
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 50 Issue 11 Pg. 1883-8 (Nov 1989) ISSN: 0002-9645 [Print] United States
PMID2619118 (Publication Type: Journal Article)
Chemical References
  • Saline Solution, Hypertonic
Topics
  • Animals
  • Blood Flow Velocity
  • Blood Pressure
  • Cat Diseases (therapy)
  • Cats
  • Hemodynamics
  • Infusions, Intra-Arterial (veterinary)
  • Infusions, Intravenous (veterinary)
  • Myocardial Contraction
  • Random Allocation
  • Saline Solution, Hypertonic (therapeutic use)
  • Shock (therapy, veterinary)
  • Vascular Resistance

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: