Pituitary macroadenomas (>3 cm) in young adulthood: Pathologic and proliferative characteristics.

There are scarce data regarding the significance of the tumor size, hormonal activity and size of the pituitary tumor of the young; therefore, the study was designed to define the relation of the hormonal status of the large pituitary adenomas.
We compared those features with tumors of the elderly (>40) with the young patients, and analyzed the clinicopathologic and proliferative features of pituitary macroadenomas in young adulthood (≤40).
20-year archives of pituitary tumors in our clinics were reviewed and macroadenomas with diameter≥3 cm were included in the study. We identified 46 pituitary adenomas and immunohistochemically stained them with pituitary hormones, p53 and Ki-67. Twenty-four cases were ≤40-year with an age range of 11-40 years (mean 28.0). Twenty-two cases were >40 with an age range of 44-78 years (mean 58.8).
In the young patient group, 15 (62.5%) were functional adenomas (6 prolactinomas, six growth hormone [GH], one adrenocorticotrophic hormone [ACTH] adenoma, two multihormonal [GH+ACTH]) and nine (37.5%) were either gonadotrophic or null cell adenomas. In the elderly group, five (22.7%) were functional adenomas (two adrenocorticotrophic hormone [ACTH] adenoma, one prolactinoma, one growth hormone [GH], one multihormonal [GH+ACTH]) and 17 (77.3%) were either gonadotrophic or null cell adenomas. Ki-67 proliferation index in adenomas of the young was approximately two-folds higher than the elderly (2.7% vs. 1.2%).
In both groups, rare p53 positivity was identified. In conclusion, pituitary macroadenomas of the young show hormonal expression frequently with relatively high Ki-67 proliferation indices.
AuthorsÖnder Öngürü, Bülent Düz, Hakan Şimşek, Armağan Günal, Engin Gönül
JournalNeurologia i neurochirurgia polska (Neurol Neurochir Pol) Vol. 49 Issue 4 Pg. 212-6 ( 2015) ISSN: 0028-3843 [Print] Poland
PMID26188936 (Publication Type: Journal Article)
CopyrightCopyright © 2015 Polish Neurological Society. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
Chemical References
  • Ki-67 Antigen
  • Tumor Suppressor Protein p53
  • Adenoma (pathology)
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Child
  • Female
  • Humans
  • Ki-67 Antigen (metabolism)
  • Male
  • Middle Aged
  • Pituitary Neoplasms (pathology)
  • Tumor Suppressor Protein p53 (metabolism)
  • Young Adult

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