[Studies of tryptophan metabolism in cancer of the urinary bladder].

Abstract

In 100 patients suffering from urinary bladder cancer (pTA-4, Nx, M0-1, G0-3) we created an oral tryptophan load administering 5 g of L-type tryptophan. Thereafter the amount of both xanthurenic acid and kynurenin was determined quantitatively in the 24-hour urine. 16 patients revealed pathological test results and excretion pattern of tryptophan metabolites via kynurenin were similar to vitamin B6-dependent xanthurenic aciduria both in its homocygotic and heterocygotic pattern. It has not been possible to prove a direct correlation between xanthurenic aciduria and urinary bladder cancer. However, xanthurenic aciduria may be of significance as a risk factor in the etiopathogenesis of urinary bladder cancer.

• Authors: H Wich, U Grimm, A Knapp
• Journal: Zeitschrift fur Urologie und Nephrologie (Z Urol Nephrol) Vol. 82 Issue 11 Pg. 593-6 (Nov 1989) ISSN: 0044-3611 [Print] Germany
• Vernacular Title: Tryptophanstoffwechseluntersuchungen beim Harnblasenkarzinom.
• PMID: 2618183 (Publication Type: English Abstract, Journal Article)

Chemical References

• Xanthurenates
• Kynurenine
• xanthurenic acid
• Tryptophan

Topics

• Humans
• Kynurenine (urine)
• Risk Factors
• Tryptophan (pharmacokinetics)
• Urinary Bladder Neoplasms (diagnosis, etiology, urine)
• Xanthurenates (urine)