Abstract | BACKGROUND AND PURPOSE: METHODS: Male CD-1 mice (n=176) were subjected to intrastriatal infusion of bacterial collagenase (n=126), autologous blood (n=18) or sham surgery (n=32). Four (4) animals not subjected to ICH (naive) were also included in the study. After ICH, animals either received vehicle, dimethyl fumarate (10 mg or 100 mg/kg) or casein kinase 2 inhibitor (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid (TBCA). Thirty-two mice also received scrambled siRNA or MAFG siRNA 24h before ICH. Brain water content and neurological function were evaluated. RESULTS: CONCLUSION:
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Authors | Loretta O Iniaghe, Paul R Krafft, Damon W Klebe, Eric K I Omogbai, John H Zhang, Jiping Tang |
Journal | Neurobiology of disease
(Neurobiol Dis)
Vol. 82
Pg. 349-358
(Oct 2015)
ISSN: 1095-953X [Electronic] United States |
PMID | 26176793
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid
- Acrylates
- Icam1 protein, mouse
- MafG Transcription Factor
- Mafg protein, mouse
- NF-E2-Related Factor 2
- Neuroprotective Agents
- Nfe2l2 protein, mouse
- Protein Kinase Inhibitors
- Repressor Proteins
- Intercellular Adhesion Molecule-1
- Casein Kinase II
- Collagenases
- Dimethyl Fumarate
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Topics |
- Acrylates
(pharmacology)
- Animals
- Blood-Brain Barrier
(drug effects, enzymology)
- Brain Edema
(drug therapy, enzymology)
- Casein Kinase II
(antagonists & inhibitors, metabolism)
- Cerebral Hemorrhage
(drug therapy, enzymology)
- Collagenases
- Dimethyl Fumarate
(pharmacology)
- Disease Models, Animal
- Intercellular Adhesion Molecule-1
(metabolism)
- MafG Transcription Factor
(genetics, metabolism)
- Male
- Mice
- Microglia
(drug effects, enzymology)
- NF-E2-Related Factor 2
(metabolism)
- Neuroimmunomodulation
(drug effects, physiology)
- Neuroprotective Agents
(pharmacology)
- Phosphorylation
(drug effects)
- Protein Kinase Inhibitors
(pharmacology)
- Repressor Proteins
(genetics, metabolism)
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