Abstract | BACKGROUND: METHODS: In the present study, we evaluated the therapeutic effects of various doses of MSCs on elastase-induced emphysema in mice. When 3 different doses of MSCs were intravenously injected into mice treated with elastase, only 5×10(4) MSCs showed a significant effect on the emphysematous mouse lung. We also identified action mechanisms of MSCs based on apoptosis, lung regeneration, and protease/ antiprotease imbalance. RESULTS: CONCLUSION: This is the first study on the optimal dose of MSCs as a therapeutic candidate. This data may provide important basic data for determining dosage in clinical application of MSCs in emphysema patients.
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Authors | You-Sun Kim, Ji-Young Kim, Jin Won Huh, Sei Won Lee, Soo Jin Choi, Yeon-Mok Oh |
Journal | Tuberculosis and respiratory diseases
(Tuberc Respir Dis (Seoul))
Vol. 78
Issue 3
Pg. 239-45
(Jul 2015)
ISSN: 1738-3536 [Print] Korea (South) |
PMID | 26175778
(Publication Type: Journal Article)
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