Gd-EOB-DTPA-enhanced magnetic resonance imaging for bile duct intraductal papillary mucinous neoplasms.

Abstract

AIM:

To investigate gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) of intraductal papillary mucinous neoplasms of the bile duct (IPMN-B).

METHODS:

The imaging findings of five cases of IPMN-B which were pathologically confirmed at our hospital between March 2012 and May 2013 were retrospectively analyzed. Three of these cases were diagnosed by duodenal endoscopy and biopsy pathology, and two cases were diagnosed by surgical pathology. All five patients underwent enhanced and non-enhanced computed tomography (CT), magnetic resonance cholangiopancreatography, and Gd-EOB-DTPA-enhanced MRI; one case underwent both Gd-EOB-DTPA-enhanced MRI and positron emission tomography-CT. The clinical data and imaging results for these cases were compared and are presented.

RESULTS:

Conventional imaging showed diffuse dilatation of bile ducts and multiple intraductal polypoid and papillary neoplasms or serrated changes along the bile ducts. In two cases, Gd-EOB-DTPA-enhanced MRI revealed dilated biliary ducts and intraductal tumors, as well as filling defects caused by mucin in the dilated bile ducts in the hepatobiliary phase. Gd-EOB-DTPA-enhanced MRI in one case clearly showed a low-signal tumor in the hepatobiliary phase, similar to what was seen by positron emission tomography-CT. In two patients, routine inspection was unable to discern whether the lesions were inflammation or tumors. However, Gd-EOB-DTPA-enhanced MRI revealed a pattern of gradual enhancement during the hepatobiliary phase, and the signal intensity of the lesions was lower than the surrounding liver parenchyma, suggesting tissue inflammation in both cases, which were confirmed by surgical pathology.

CONCLUSION:

Gd-EOB-DTPA-enhanced MRI reveals the intraductal mucin component of IPMN-B in some cases and the extent of tumor infiltration beyond the bile ducts in invasive cases.

• Authors: Shi-Hong Ying, Xiao-Dong Teng, Zhao-Ming Wang, Qi-Dong Wang, Yi-Lei Zhao, Feng Chen, Wen-Bo Xiao
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 21 Issue 25 Pg. 7824-33 (Jul 07 2015) ISSN: 2219-2840 [Electronic] United States
• PMID: 26167082 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• gadolinium ethoxybenzyl DTPA
• Gadolinium DTPA

Topics

• Aged
• Bile Duct Neoplasms (diagnostic imaging, pathology, surgery)
• Cholangiopancreatography, Magnetic Resonance
• Contrast Media
• Diffusion Magnetic Resonance Imaging
• Female
• Gadolinium DTPA
• Humans
• Male
• Middle Aged
• Multidetector Computed Tomography
• Multimodal Imaging
• Neoplasm Invasiveness
• Neoplasms, Cystic, Mucinous, and Serous (diagnostic imaging, pathology, surgery)
• Positron-Emission Tomography
• Predictive Value of Tests
• Prognosis
• Retrospective Studies
• Ultrasonography, Doppler, Color