Oxidative stress and menopause-related hot flashes may be independent events.

Abstract

OBJECTIVE:

At present, there is growing demand for alternative, or additional, treatments to hormone replacement therapy for menopause-related hot flashes (HF). Antioxidant supplements have been recently proposed as possible candidates for this purpose, regardless of the absence of clear evidence in support of a link between these vasomotor symptoms and oxidative stress (OxS). The aim of our study was to evaluate the association between HF and OxS serum markers in a large sample of middle-aged women.

MATERIALS AND METHODS:

We conducted a cross-sectional study on 245 perimenopausal and early postmenopausal women (age 45-60 years). The variables examined were presence of self-reported HF and levels of 8-iso-prostaglandin F2α, 8-OH-deoxy-2'-guanosine, advanced oxidation protein products, total antioxidant power, uric acid, thiols, and paroxonase-1.

RESULTS:

Seventy-six women (31%) reported to suffer from HF (either medium or high intensity). None of the peripheral markers of OxS examined was found to be significantly associated with the presence of HF.

CONCLUSION:

Taken together, our data suggest that systemic OxS might not be implicated with the onset of the climacteric vasomotor symptoms that most commonly affect women experiencing perimenopause and early postmenopause.

• Authors: Gloria Bonaccorsi, Arianna Romani, Eleonora Cremonini, Carlo M Bergamini, Maria Cristina Castaldini, Enrica Fila, Stefania Hanau, Leo Massari, Carlo Cervellati
• Journal: Taiwanese journal of obstetrics & gynecology (Taiwan J Obstet Gynecol) Vol. 54 Issue 3 Pg. 290-3 (Jun 2015) ISSN: 1875-6263 [Electronic] China (Republic : 1949- )
• PMID: 26166343 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015. Published by Elsevier B.V.

Chemical References

• Advanced Oxidation Protein Products
• Antioxidants
• Sulfhydryl Compounds
• Uric Acid
• 8-epi-prostaglandin F2alpha
• 8-Hydroxy-2'-Deoxyguanosine
• Dinoprost
• Aryldialkylphosphatase
• PON1 protein, human
• Deoxyguanosine

Topics

• 8-Hydroxy-2'-Deoxyguanosine
• Advanced Oxidation Protein Products (blood)
• Antioxidants
• Aryldialkylphosphatase (blood)
• Case-Control Studies
• Cross-Sectional Studies
• Deoxyguanosine (analogs & derivatives, urine)
• Dinoprost (analogs & derivatives, urine)
• Female
• Hot Flashes (blood, urine)
• Humans
• Menopause (physiology)
• Middle Aged
• Oxidative Stress (physiology)
• Sulfhydryl Compounds (blood)
• Surveys and Questionnaires
• Uric Acid (blood)